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Lundby 2013 Abstract MiP2013

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Lundby C, Bonne T, Flรผck D, Jacobs R, Meinild AK, Lundby S, Robach P (2013) The effects of hypoxic training on aerobic performance in normoxia and moderate hypoxia: a randomized, double blind, placebo controlled study. Mitochondr Physiol Network 18.08.


Carsten Lundby

MiP2013, Book of Abstracts Open Access

Lundby C, Bonne T, Flueck D, Jacobs R, Meinild AK, Lundby S, Robach P (2013)

Event: MiPNet18.08 MiP2013

The effects of hypoxic training on exercise performance remain controversial. To test the hypotheses that (i) hypoxic training possesses ergogenic effects at sea-level and altitude, and (ii) the benefits are primarily mediated by improved mitochondrial function of skeletal muscle, we determined aerobic performance (incremental test to exhaustion and time trial) in moderately-trained subjects undergoing six weeks of endurance training (3-4 times/week, 60 min/session) in normoxia (placebo, N=8) or normobaric hypoxia (FIO2=0.15; N=9) using a double blinded and randomized design . Exercise tests were performed in normoxia and acute hypoxia (FIO2=0.15). Mitochondrial oxidative capacity and efficiency were quantified from skeletal muscle biopsies. Total hemoglobin mass (Hbmass) was measured by carbon-monoxide rebreathing. Neither maximal capacity of oxidative phosphorylation nor mitochondrial efficiency was altered by training or hypoxia. Hypoxic training increased Hbmass more than placebo (8.4 vs 3.3%, P=0.03). In normoxia, hypoxic training had no additive effect on maximal oxygen uptake (VO2max), time trial performance or cycling efficiency. In acute hypoxia, hypoxic training conferred no advantage on VO2max, but improved cycling efficiency, and tended to enhance time trial performance (52 vs 32%, P=0.09). Our data suggest that training in hypoxia possesses no ergogenic effect at sea level, but may confer some advantage for endurance performance at moderate altitude, possibly through Hbmass expansion.

โ€ข O2k-Network Lab: CH Zurich Lundby C, US CO Colorado Springs Jacobs RA

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 

Stress:Ischemia-reperfusion  Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 

Coupling state: OXPHOS 

HRR: Oxygraph-2k 


Affiliations and author contributions

Zurich Center for Integrative Human Physiology (ZIHP), Institute of Physiology, University of Zurich, Switzerland. - Email: