Marin 2023 Exp Gerontol

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Marin CT, de Souza Lino AD, Avelar IDS, Barbosa MR, Scarlato GCG, Cavalini DF, Tamanini F, Alexandrino AV, Vercesi AE, Shiguemoto GE (2023) Resistance training prevents dynamics and mitochondrial respiratory dysfunction in vastus lateralis muscle of ovariectomized rats.

Β» Exp Gerontol 173:112081. PMID: 36608776 Open Access

Tardivo Marin Cecilia, de Souza Lino Anderson Diogo,  Santos Avelar Iara Dinik,  Barbosa Marina Rodrigues,  Scarlato Gabriel Carlos Goulart,  Cavalini Diego Felipe,  Tamanini Fabio,  Alexandrino Andre Vessoni, Vercesi Anibal Eugenio,  Shiguemoto Gilberto Eiji (2023) Exp Gerontol

Abstract: To investigate whether ovariectomy affects mitochondrial respiratory function, gene expression of the biogenesis markers and mitochondrial dynamics of the vastus lateralis muscle, female Wistar rats divided into ovariectomized (OVX) and intact (INT) groups were kept sedentary (SED) or submitted to resistance training (RT) performed for thirteen weeks on a vertical ladder in which animals climbed with a workload apparatus. RT sessions were performed with four climbs with 65, 85, 95, and 100 % of the rat's previous maximum workload. Mitochondrial Respiratory Function data were obtained by High-resolution respirometry. Gene expression of FIS1, MFN1 and PGC1-Ξ± was evaluated by real-time PCR. There was a decrease on oxidative phosphorylation capacity in OVX-SED compared to other groups. Trained groups presented increase on oxidative phosphorylation capacity when compared to sedentary groups. For respiratory control ratio (RCR), OVX-SED presented lower values when compared to INT-SED and to trained groups. Trained groups presented RCR values higher compared to INT-SED. Exercise increased the values of FIS1, MFN1 and PGC1-Ξ± expression compared to OVX-SED. Our results demonstrated that in the absence of ovarian hormones, there is a great decrease in oxidative phosphorylation and electron transfer system capacities of sedentary animals. RT was able to increase the expression of genes related to mitochondrial dynamics markers, reversing the condition determined by ovariectomy. β€’ Keywords: Mitochondrial dynamics, Mitochondrial dysfunction, OXPHOS, Ovariectomy, Resistance training β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: BR Campinas Vercesi AE

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 

Organism: Rat  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 

Coupling state: LEAK, OXPHOS, ET  Pathway:HRR: Oxygraph-2k 


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