Difference between revisions of "Mitochondria"
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|description='''Mitochondria''' (Greek ''mitos'': thread; ''chondros'': granule) are small structures within cells, which function in cell respiration as powerhouses or batteries. Mitochondria belong to the '''[[bioblasts]]''' of Richard Altmann. Abbreviation: mt, as generally used in mtDNA. Singular: mitochondrion (bioblast); plural: mitochondria (bioblasts). | |description='''Mitochondria''' (Greek ''mitos'': thread; ''chondros'': granule) are small structures within cells, which function in cell respiration as powerhouses or batteries. Mitochondria belong to the '''[[bioblasts]]''' of Richard Altmann. Abbreviation: mt, as generally used in mtDNA. Singular: mitochondrion (bioblast); plural: mitochondria (bioblasts). | ||
| | |info=Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v3. - [[Gnaiger 2019 MitoFit Preprint Arch |»MitoFit Preprint Arch«]] | ||
}} | }} | ||
{{MitoPedia concepts| | {{MitoPedia concepts | ||
|mitopedia concept=MiP concept | |||
}} | }} | ||
{{MitoPedia methods | {{MitoPedia methods}} | ||
}} | {{MitoPedia O2k and high-resolution respirometry}} | ||
{{MitoPedia O2k and high-resolution respirometry | {{MitoPedia topics}} | ||
}} | == Mitochondria are the electric engines in our cells == | ||
{{MitoPedia topics | |||
:::: Mitochondria burn the calories of food and convert them into useful work. How fast do our mitochondrial engines run? With the world-wide successful Oroboros O2k instrument, scientists measure oxygen consumption or cell respiration. With oxygen sensors the O2k addresses the question of rate: how fast does the engine run? | |||
The field of mitochondrial physiology might gain by aiming at a consensus on the abbreviation for 'mitochondrial'. It is not best practice to use in the same context 'mt' for '''mtDNA''', but 'mi' for '''miCK''' (mitochondrial [[creatine kinase]]; compare miRNA), and 'm' for '''mPTP''' (mitochondrial [[Talk:Mitochondria|permeability transition pore]]). The use of 'mt' in mtDNA seems to be most common and robust, hence the suggestion to use '''mtCK''', etc. --[[Gnaiger_E|Gnaiger Erich]] 07:01, 24 April 2012 (CEST) | :::: The [[NextGen-O2k]] combines measurement of O2 flux (how fast?) with recording of the redox state of Coenzyme Q. An integrated new Q-sensor provides information on the state of the engine: how hot does it get (actually: how reduced or oxidized does it get). Our mitochondrial engines may run fast, but they may burn out if they get too hot. The new Q-sensor thus adds diagnostic core information on pathologies, which will make the NextGen-O2k the leading technology for mitochondrial research and medicine. This revolutionary all-in-one device is the next step to conquer mitochondrial disease. | ||
== Mitochondrial disease == | |||
:::: Among 4,000 people, 1 is a patient affected by mitochondrial disease - a deadly pathology, progressive, little understood, and therefore largely without hope for a cure. Beyond mitochondrial diseases, mitochondria are recognized as key players in disease related to a sedentary lifstyle and aging, such as Alzheimer's. The Oroboros O2k technology supports research to make a difference. | |||
== mt == | |||
:::: The field of mitochondrial physiology might gain by aiming at a consensus on the abbreviation for 'mitochondrial'. It is not best practice to use in the same context 'mt' for '''mtDNA''', but 'mi' for '''miCK''' (mitochondrial [[creatine kinase]]; compare miRNA), and 'm' for '''mPTP''' (mitochondrial [[Talk:Mitochondria|permeability transition pore]]). The use of 'mt' in mtDNA seems to be most common and robust, hence the suggestion to use '''mtCK''', etc. --[[Gnaiger_E|Gnaiger Erich]] 07:01, 24 April 2012 (CEST) | |||
Continue the discussion: [[Talk:Mitochondria]] | Continue the discussion: [[Talk:Mitochondria]] | ||
Revision as of 19:28, 5 May 2019
- high-resolution terminology - matching measurements at high-resolution
Mitochondria
Description
Mitochondria (Greek mitos: thread; chondros: granule) are small structures within cells, which function in cell respiration as powerhouses or batteries. Mitochondria belong to the bioblasts of Richard Altmann. Abbreviation: mt, as generally used in mtDNA. Singular: mitochondrion (bioblast); plural: mitochondria (bioblasts).
Abbreviation: mt
Reference: Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v3. - »MitoFit Preprint Arch«
MitoPedia concepts:
MiP concept
Mitochondria are the electric engines in our cells
- Mitochondria burn the calories of food and convert them into useful work. How fast do our mitochondrial engines run? With the world-wide successful Oroboros O2k instrument, scientists measure oxygen consumption or cell respiration. With oxygen sensors the O2k addresses the question of rate: how fast does the engine run?
- The NextGen-O2k combines measurement of O2 flux (how fast?) with recording of the redox state of Coenzyme Q. An integrated new Q-sensor provides information on the state of the engine: how hot does it get (actually: how reduced or oxidized does it get). Our mitochondrial engines may run fast, but they may burn out if they get too hot. The new Q-sensor thus adds diagnostic core information on pathologies, which will make the NextGen-O2k the leading technology for mitochondrial research and medicine. This revolutionary all-in-one device is the next step to conquer mitochondrial disease.
Mitochondrial disease
- Among 4,000 people, 1 is a patient affected by mitochondrial disease - a deadly pathology, progressive, little understood, and therefore largely without hope for a cure. Beyond mitochondrial diseases, mitochondria are recognized as key players in disease related to a sedentary lifstyle and aging, such as Alzheimer's. The Oroboros O2k technology supports research to make a difference.
mt
- The field of mitochondrial physiology might gain by aiming at a consensus on the abbreviation for 'mitochondrial'. It is not best practice to use in the same context 'mt' for mtDNA, but 'mi' for miCK (mitochondrial creatine kinase; compare miRNA), and 'm' for mPTP (mitochondrial permeability transition pore). The use of 'mt' in mtDNA seems to be most common and robust, hence the suggestion to use mtCK, etc. --Gnaiger Erich 07:01, 24 April 2012 (CEST)
Continue the discussion: Talk:Mitochondria
