Difference between revisions of "Mitochondrial free radical theory of aging"
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|abbr=MFRTA | |abbr=MFRTA | ||
|description=The '''mitochondrial free radical theory of aging''' goes back to Harman (1956) and ranks among the most popular theories of aging. It is based on postulates which are not unequivocally supported by | |description=The '''mitochondrial free radical theory of aging''' goes back to Harman (1956) and ranks among the most popular theories of aging. It is based on postulates which are not unequivocally supported by observation (Bratic, Larsson 2013): | ||
(i) Mitochondrial ROS production increases with age caused by progressive mitochondrial dysfunction; | |||
mitochondrial dysfunction; | (ii) antioxidat capacity declines with age; | ||
(iii) mutations of somatic mtDNA accumulate during aging; | |||
(iv) a vicious cycle occurs of increased ROS production caused by mtDNA mutations and degenerated mt-function, and due to ROS-induced ROS production. | |||
|info=[[Bratic 2013 J Clin Invest]] | |info=[[Bratic 2013 J Clin Invest]] | ||
}} | }} | ||
Latest revision as of 13:08, 10 September 2013
- high-resolution terminology - matching measurements at high-resolution
Mitochondrial free radical theory of aging
Description
The mitochondrial free radical theory of aging goes back to Harman (1956) and ranks among the most popular theories of aging. It is based on postulates which are not unequivocally supported by observation (Bratic, Larsson 2013): (i) Mitochondrial ROS production increases with age caused by progressive mitochondrial dysfunction; (ii) antioxidat capacity declines with age; (iii) mutations of somatic mtDNA accumulate during aging; (iv) a vicious cycle occurs of increased ROS production caused by mtDNA mutations and degenerated mt-function, and due to ROS-induced ROS production.
Abbreviation: MFRTA
Reference: Bratic 2013 J Clin Invest
References
- Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298–300.
- Bratic A, Larsson NG (2013) The role of mitochondria in aging. J Clin Invest 123: 951-957.
