Difference between revisions of "OXPHOS capacity"
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{{MitoPedia | {{MitoPedia | ||
|abbr=''P'' | |abbr=''P'' | ||
|description='''OXPHOS capacity''' is the respiratory capacity of mitochondria in the ADP-activated state of [[oxidative phosphorylation]], at saturating concentrations of [[ADP]], inorganic phosphate, oxygen, and defined reduced substrates | |description='''OXPHOS capacity''' (''P''; compare [[State 3]]) is the respiratory capacity of mitochondria in the ADP-activated state of [[oxidative phosphorylation]], at saturating concentrations of [[ADP]], inorganic phosphate, oxygen, and defined reduced substrates. Since OXPHOS is partially coupled, intrinsic [[uncoupling]] and [[dyscoupling]] contribute to the control of flux in the OXPHOS state (state ''P''). OXPHOS capacity is expressed (i) per mt-marker (mt-protein, [[CS]], etc); if ETS capacity, ''E'', is used as a functional mitochondrial marker, then OXPHOS capacity is expressed as the ''[[P/E]]'' ratio. (ii) OXPHOS capacity is expressed per tissue or cell mass, integrating mt-quantity (density) and mt-quality. (iii) OXPHOS capacity is expressed per cell, which then is a function of mt-density, mt-quality, and cell size. | ||
|info=MiPNet12.15, Gnaiger_2009_IJBCB | |info=MiPNet12.15, Gnaiger_2009_IJBCB | ||
|type=Respiration | |type=Respiration | ||
Revision as of 21:52, 16 October 2010
- high-resolution terminology - matching measurements at high-resolution
OXPHOS capacity
Description
OXPHOS capacity (P; compare State 3) is the respiratory capacity of mitochondria in the ADP-activated state of oxidative phosphorylation, at saturating concentrations of ADP, inorganic phosphate, oxygen, and defined reduced substrates. Since OXPHOS is partially coupled, intrinsic uncoupling and dyscoupling contribute to the control of flux in the OXPHOS state (state P). OXPHOS capacity is expressed (i) per mt-marker (mt-protein, CS, etc); if ETS capacity, E, is used as a functional mitochondrial marker, then OXPHOS capacity is expressed as the P/E ratio. (ii) OXPHOS capacity is expressed per tissue or cell mass, integrating mt-quantity (density) and mt-quality. (iii) OXPHOS capacity is expressed per cell, which then is a function of mt-density, mt-quality, and cell size.
Abbreviation: P
Reference: MiPNet12.15, Gnaiger_2009_IJBCB
Labels:
Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property., Permeabilized Cell or Tissue; Homogenate"Permeabilized Cell or Tissue; Homogenate" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
