Difference between revisions of "Oliveira 2011 Insect Biochem Mol Biol"
Bader Helga (talk | contribs) |
|||
| Line 1: | Line 1: | ||
{{Publication | {{Publication | ||
|title=Oliveira JH, Gonçalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury C (2011) Energy metabolism affects susceptibility of ''Anopheles gambiae'' mosquitoes to ''Plasmodium'' infection. Insect Biochem Mol Biol 41: 349- | |title=Oliveira JH, Gonçalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury C (2011) Energy metabolism affects susceptibility of ''Anopheles gambiae'' mosquitoes to ''Plasmodium'' infection. Insect Biochem Mol Biol 41:349-55. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/21320598 PMID:21320598] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/21320598 PMID:21320598] | ||
|authors=Oliveira JH, Goncalves RL , Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury M | |authors=Oliveira JH, Goncalves RL , Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury M | ||
| Line 12: | Line 12: | ||
{{Labeling | {{Labeling | ||
|taxonomic group=Hexapods | |taxonomic group=Hexapods | ||
|injuries=RONS | |injuries=Oxidative stress;RONS | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
}} | }} | ||
Revision as of 16:43, 23 February 2015
| Oliveira JH, Gonçalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury C (2011) Energy metabolism affects susceptibility of Anopheles gambiae mosquitoes to Plasmodium infection. Insect Biochem Mol Biol 41:349-55. |
Oliveira JH, Goncalves RL, Oliveira GA, Oliveira PL, Oliveira MF, Barillas-Mury M (2011) Insect Biochem Mol Biol
Abstract: Previous studies showed that Anopheles gambiae L3-5 females, which are refractory (R) to Plasmodium infection, express higher levels of genes involved in redox-metabolism and mitochondrial respiration than susceptible (S) G3 females. Our studies revealed that R females have reduced longevity, faster utilization of lipid reserves, impaired mitochondrial State 3 respiration, increased rate of mitochondrial electron leak and higher expression levels of several glycolytic enzyme genes. Furthermore, when State 3 respiration was reduced in S females by silencing expression of the adenine nucleotide translocator (ANT), hydrogen peroxide generation was higher and the mRNA levels of lactate dehydrogenase increased in the midgut, while the prevalence and intensity of Plasmodiumberghei infection were significantly reduced. We conclude that there are broad metabolic differences between R and S An. gambiae mosquitoes that influence their susceptibility to Plasmodium infection. • Keywords: Mosquito; Anopheles gambiae; Metabolism; Mitochondria; Plasmodium infection; Refractoriness; Electron leak; Reactive oxygen species
• O2k-Network Lab: BR_Rio de Janeiro_Oliveira MF
Labels:
Stress:Oxidative stress;RONS
HRR: Oxygraph-2k
