Difference between revisions of "P/E control ratio"
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|abbr=''P/E'' | |abbr=''P/E'' | ||
|description=The '''phosphorylation system control ratio''' or OXPHOS/ETS (''P/E'') ratio is an expression of the limitation of OXPHOS capacity by the [[phosphorylation system]]. The ''P/E'' ratio increases with increasing capacity of the phosphorylation system up to a maximum of 1.0 when it matches or is in excess of ETS capacity. ''P/E'' also increases with uncoupling. ''P/E'' increases from the lower boundary set by ''[[L/E]]'' (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of ''P'' by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the [[ETS capacity]]; or if the system is fully [[uncoupled]]). It is important to separate the kinetic effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration. | |description=The '''phosphorylation system control ratio''' or OXPHOS/ETS (''P/E'') ratio is an expression of the limitation of OXPHOS capacity by the [[phosphorylation system]]. The ''P/E'' ratio increases with increasing capacity of the phosphorylation system up to a maximum of 1.0 when it matches or is in excess of ETS capacity. ''P/E'' also increases with uncoupling. ''P/E'' increases from the lower boundary set by ''[[L/E]]'' (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of ''P'' by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the [[ETS capacity]]; or if the system is fully [[uncoupled]]). It is important to separate the kinetic effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration. | ||
|info=[[MiPNet12.15]], [[Gnaiger_2009_IJBCB]], [[Pesta_2011_Protocols]]; [[ | |info=[[MiPNet12.15]], [[Gnaiger_2009_IJBCB]], [[Pesta_2011_Protocols]]; [[List of respiratory states]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
Revision as of 10:48, 28 February 2011
- high-resolution terminology - matching measurements at high-resolution
P/E control ratio
Description
The phosphorylation system control ratio or OXPHOS/ETS (P/E) ratio is an expression of the limitation of OXPHOS capacity by the phosphorylation system. The P/E ratio increases with increasing capacity of the phosphorylation system up to a maximum of 1.0 when it matches or is in excess of ETS capacity. P/E also increases with uncoupling. P/E increases from the lower boundary set by L/E (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of P by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the ETS capacity; or if the system is fully uncoupled). It is important to separate the kinetic effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration.
Abbreviation: P/E
Reference: MiPNet12.15, Gnaiger_2009_IJBCB, Pesta_2011_Protocols; List of respiratory states
Labels:
Enzyme: Complex V; ATP Synthase"Complex V; ATP Synthase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property., Adenine Nucleotide Translocase"Adenine Nucleotide Translocase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property., Inner mtMembrane Transporter"Inner mtMembrane Transporter" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Respiratory state"Respiratory state" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
P/E and respiratory control ratio
- The P/E ratio is discussed in: Talk:ETS capacity
- Can P/E be higher than 1.0? See Talk:Phosphorylation system control ratio
