P/E control ratio

high-resolution terminology - matching measurements at high-resolution

P/E control ratio

Description

The phosphorylation system control ratio or OXPHOS/ETS (P/E) ratio is an expression of the limitation of OXPHOS capacity by the phosphorylation system. The P/E ratio increases with increasing capacity of the phosphorylation system up to a maximum of 1.0 when it matches or is in excess of ETS capacity. P/E also increases with uncoupling. P/E increases from the lower boundary set by L/E (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of P by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the ETS capacity; or if the system is fully uncoupled). It is important to separate the kinetic effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration.

Abbreviation: P/E

Reference: MiPNet12.15, Gnaiger_2009_IJBCB, Pesta_2011_Protocols; List of respiratory states

MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. 

P/E and respiratory control ratio

• The P/E ratio is discussed in: Talk:ETS capacity
• Can P/E be higher than 1.0? See Talk:Phosphorylation system control ratio