Difference between revisions of "P/E control ratio"
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{{MitoPedia | {{MitoPedia | ||
|abbr=P/E | |abbr=''P/E'' | ||
|description=The OXPHOS control ratio or OXPHOS/ETS | |description=The '''OXPHOS control ratio''' or OXPHOS/ETS ratio decreases with limitation by the [[phosphorylation system]]. P/E increases from the lower boundary set by [[L/E]] (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of ''P'' by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the [[ETS capacity]]; or if the system is fully [[uncoupled]]). It is important to separate the effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration. | ||
|info=[[MiPNet12.15]], [[ | |info=[[MiPNet12.15]], [[Gnaiger_2009_IJBCB]], [[Pesta_2010_Protocols]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
|topics=Respiration; OXPHOS; ETS Capacity | |topics=Respiration; OXPHOS; ETS Capacity, Coupling; Membrane Potential | ||
|enzymes=Complex V; ATP Synthase, Adenine Nucleotide Translocase, Inner mtMembrane Transporter | |||
}} | }} | ||
* The ''P/E'' ratio is discussed in: [[Talk:ETS capacity]] | |||
Revision as of 22:50, 18 September 2010
- high-resolution terminology - matching measurements at high-resolution
P/E control ratio
Description
The OXPHOS control ratio or OXPHOS/ETS ratio decreases with limitation by the phosphorylation system. P/E increases from the lower boundary set by L/E (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of P by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the ETS capacity; or if the system is fully uncoupled). It is important to separate the effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration.
Abbreviation: P/E
Reference: MiPNet12.15, Gnaiger_2009_IJBCB, Pesta_2010_Protocols
Labels:
Enzyme: Complex V; ATP Synthase"Complex V; ATP Synthase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property., Adenine Nucleotide Translocase"Adenine Nucleotide Translocase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property., Inner mtMembrane Transporter"Inner mtMembrane Transporter" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
- The P/E ratio is discussed in: Talk:ETS capacity
