Difference between revisions of "Paradies 2014 Biochim Biophys Acta"
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|keywords=Cardiolipin, Mitochondrial bioenergetics | |keywords=Cardiolipin, Mitochondrial bioenergetics | ||
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== Cited by == | |||
{{Template:Cited by Gnaiger 2020 BEC MitoPhysiology}} | |||
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|additional=Review, | |area=mt-Membrane | ||
|enzymes=Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter | |||
|injuries=Cell death, Permeability transition | |||
|additional=Review, BEC 2020.1 | |||
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Latest revision as of 18:57, 16 January 2021
Paradies G, Paradies V, De Benedictis V, Ruggiero FM, Petrosillo G (2014) Functional role of cardiolipin in mitochondrial bioenergetics. Biochim Biophys Acta 1837:408-17. |
Paradies G, Paradies V, De Benedictis V, Ruggiero FM, Petrosillo G (2014) Biochim Biophys Acta
Abstract: Cardiolipin is a unique phospholipid which is almost exclusively located in the inner mitochondrial membrane where it is biosynthesized. Considerable progress has recently been made in understanding the role of cardiolipin in mitochondrial function and bioenergetics. This phospholipid is associated with membranes designed to generate an electrochemical gradient that is used to produce ATP, such as bacterial plasma membranes and inner mitochondrial membrane. This ubiquitous and intimate association between cardiolipin and energy transducing membranes indicates an important role for cardiolipin in mitochondrial bioenergetic processes. Cardiolipin has been shown to interact with a number of proteins, including the respiratory chain complexes and substrate carrier proteins. Over the past decade, the significance of cardiolipin in the organization of components of the electron transport chain into higher order assemblies, termed respiratory supercomplexes, has been established. Moreover, cardiolipin is involved in different stages of the mitochondrial apoptotic process, as well as in mitochondrial membrane stability and dynamics. This review discusses the current understanding of the functional role that cardiolipin plays in several reactions and processes involved in mitochondrial bioenergetics. This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components. β’ Keywords: Cardiolipin, Mitochondrial bioenergetics
Cited by
- Gnaiger E et al β MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1.
Labels: MiParea: mt-Membrane
Stress:Cell death, Permeability transition
Enzyme: Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter
Review, BEC 2020.1