Pereyra 2023 Am J Physiol Gastrointest Liver Physiol

From Bioblast
Revision as of 15:43, 19 December 2023 by Plangger Mario (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision β†’ (diff)
Publications in the MiPMap
Pereyra AS, McLaughlin KL, Buddo KA, Ellis JM (2023) Medium-chain fatty acid oxidation is independent of L-carnitine in liver and kidney but not in heart and skeletal muscle.

Β» Am J Physiol Gastrointest Liver Physiol 325:G287-94. PMID: 37461880 Open Access

Pereyra Andrea S, McLaughlin Kelsey L, Buddo Katherine A, Ellis Jessica M (2023) Am J Physiol Gastrointest Liver Physiol

Abstract: Medium-chain fatty acid (MCFA) consumption confers a wide range of health benefits that are highly distinct from long-chain fatty acids (LCFA). A major difference between the metabolism of LCFAs compared to MCFAs is that mitochondrial LCFA oxidation depends on the carnitine shuttle, whereas MCFA mitochondrial oxidation is not. Although MCFAs are said to range from 6 to 14 carbons long based on physicochemical properties in vitro, the biological cut-off length of acyl chains that can bypass the carnitine shuttle in different mammalian tissues is unknown. To define the range of acyl chain length that can be oxidized in the mitochondria independent of carnitine, we determined the oxidative metabolism of free fatty acids (FFAs) from 6 to 18 carbons long in the liver, kidney, heart, and skeletal muscle. The liver oxidized FFAs 6 to 14 carbons long, while the kidney oxidized FFAs from 6 to 10 carbons in length. Heart and skeletal muscle were unable to oxidize FFAs of any chain length. These data show that while the liver and kidney can oxidize MCFAs in the free form, the heart and skeletal muscle require carnitine for the oxidative metabolism of MCFAs. Together these data demonstrate that MCFA oxidation independent of carnitine is tissue-specific. β€’ Keywords: Carnitine, Liver Medium-chain fatty acids, Mitochondrial fatty acid oxidation, Skeletal muscle β€’ Bioblast editor: Plangger M

Labels: MiParea: Respiration 

Organism: Mouse  Tissue;cell: Heart, Skeletal muscle, Liver, Kidney  Preparation: Homogenate 

Regulation: Fatty acid  Coupling state: LEAK, ROUTINE, OXPHOS  Pathway: F, N  HRR: Oxygraph-2k 


Cookies help us deliver our services. By using our services, you agree to our use of cookies.