Difference between revisions of "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha"
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|abbr=PGC-1alpha | |abbr=PGC-1alpha | ||
|description='''Peroxisome proliferator-activated receptor gamma coactivator 1-alpha''' is a protein which functions as an inducible coregulator of transcription factors, such as [[NRF-1]] and [[TFAM]]. PGC-1alpha drives the formation of slow-twich muscle fibres ([[Lin_2002_Nature]]) and is increased upon endurance training ([[Norrbom_2004_J Appl Physiol]]). Upregulation of PGC-1alpha expression is induced by increased [[eNOS]] activity -> [[NO]] -> [[guanylate cyclase]] -> [[cGMP]]. | |description='''Peroxisome proliferator-activated receptor gamma coactivator 1-alpha''' is a protein which functions as an inducible coregulator of transcription factors, such as [[NRF-1]] and [[TFAM]]. PGC-1alpha drives the formation of slow-twich muscle fibres ([[Lin_2002_Nature]]) and is increased upon endurance training ([[Norrbom_2004_J Appl Physiol]]). Upregulation of PGC-1alpha expression is induced by increased [[eNOS]] activity -> [[NO]] -> [[guanylate cyclase]] -> [[cGMP]] ([[Nisoli_2007_Circ Res]]). | ||
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{{MitoPedia methods}} | {{MitoPedia methods}} | ||
{{MitoPedia topics}} | {{MitoPedia topics}} | ||
* MitoPedia topic: Genetics - Coactivator | * MitoPedia topic: Genetics - Coactivator | ||
Revision as of 02:31, 4 June 2012
- high-resolution terminology - matching measurements at high-resolution
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Description
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha is a protein which functions as an inducible coregulator of transcription factors, such as NRF-1 and TFAM. PGC-1alpha drives the formation of slow-twich muscle fibres (Lin_2002_Nature) and is increased upon endurance training (Norrbom_2004_J Appl Physiol). Upregulation of PGC-1alpha expression is induced by increased eNOS activity -> NO -> guanylate cyclase -> cGMP (Nisoli_2007_Circ Res).
Abbreviation: PGC-1alpha
- MitoPedia topic: Genetics - Coactivator
