Difference between revisions of "Piericidin"

Revision as of 13:29, 30 November 2018

high-resolution terminology - matching measurements at high-resolution

Piericidin

Description

Piericidin C₂₅H₃₇NO₄ is an antibiotic (isolated from Streptomyces mobaraensis) showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of CI (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided 1) depending of the site of action (functional classification): quinone antagonists (e.g. piericidin A, first site), semiquinone antagonists (piericidin A, second site; piericidin B; rotenone) and quinol antagonists (myxothiazol; stigmatellin) and 2) depending on their effect on ROS production: inducing ROS production (e.g. rotenone, piericidin A, Rolliniastatin-1 and -2) and preventing ROS production (e.g. stigmatellin, capsaicin, mucidin and coenzyme Q2). In plants, pieridicin A inhibits photosystem II.

MitoPedia topics: Inhibitor

Piericidin A

@@ Line 1: / Line 1: @@
 {{MitoPedia
-|description='''Piericidine''' C<sub>25</sub>H<sub>37</sub>NO<sub>4</sub> is a competitive inhibitor of [[Complex I |C<sub>I</sub>]], ubiquinone structure; antibiotic.
+|description='''Piericidin''' C<sub>25</sub>H<sub>37</sub>NO<sub>4</sub> is an antibiotic (isolated from ''Streptomyces mobaraensis'') showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of [[Complex I |CI]] (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided 1) depending of the site of action (functional classification):  quinone antagonists (e.g. piericidin A, first site), semiquinone antagonists (piericidin A, second site; piericidin B; rotenone) and quinol antagonists (myxothiazol; stigmatellin) and 2) depending on their effect on ROS production: inducing ROS production (e.g. rotenone, piericidin A, Rolliniastatin-1 and -2) and preventing ROS production (e.g. stigmatellin, capsaicin, mucidin and coenzyme Q2). In plants, pieridicin A inhibits photosystem II.
 |type=Inhibitor ETS
 }}