Difference between revisions of "Piericidin"
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|description='''Piericidin''' C<sub>25</sub>H<sub>37</sub>NO<sub>4</sub> is an antibiotic (isolated from ''Streptomyces mobaraensis'') showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of [[Complex I |CI]] (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided 1) depending of the site of action (functional classification): | |description='''Piericidin''' C<sub>25</sub>H<sub>37</sub>NO<sub>4</sub> is an antibiotic (isolated from ''Streptomyces mobaraensis'') showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of [[Complex I |CI]] (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided (''1'') depending of the site of action (functional classification): quinone antagonists (e.g. piericidin A, first site), semiquinone antagonists (piericidin A, second site; piericidin B; [[Rotenone| rotenone]] and quinol antagonists (myxothiazol; stigmatellin), and (''2'') depending on their effect on ROS production: inducing ROS production (e.g. rotenone, piericidin A, Rolliniastatin-1 and -2) and preventing ROS production (e.g. stigmatellin, capsaicin, mucidin and coenzyme Q2). In plants, pieridicin A inhibits photosystem II. | ||
| | |info=[[Jeng 1968 Biochemistry]], [[Degli 1998 Biochim Biophys Acta]], [[Fato 2009 Biochim Biophys Acta]] | ||
}} | }} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Inhibitor | |mitopedia topic=Inhibitor | ||
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* [http://www.enzolifesciences.com/ALX-380-235/piericidin-a/ Piericidin A] | ::::* [http://www.enzolifesciences.com/ALX-380-235/piericidin-a/ Piericidin A] | ||
Latest revision as of 09:28, 2 November 2020
- high-resolution terminology - matching measurements at high-resolution
Piericidin
Description
Piericidin C25H37NO4 is an antibiotic (isolated from Streptomyces mobaraensis) showing similarity with ubiquinone structure which has a potent and competitive inhibitory effect of CI (it competes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided (1) depending of the site of action (functional classification): quinone antagonists (e.g. piericidin A, first site), semiquinone antagonists (piericidin A, second site; piericidin B; rotenone and quinol antagonists (myxothiazol; stigmatellin), and (2) depending on their effect on ROS production: inducing ROS production (e.g. rotenone, piericidin A, Rolliniastatin-1 and -2) and preventing ROS production (e.g. stigmatellin, capsaicin, mucidin and coenzyme Q2). In plants, pieridicin A inhibits photosystem II.
Reference: Jeng 1968 Biochemistry, Degli 1998 Biochim Biophys Acta, Fato 2009 Biochim Biophys Acta
MitoPedia topics:
Inhibitor
