Ryu 2010 FEBS Lett
| Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS (2010) Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett 584:1948-55. |
Ryu Shin-Young, Beutner Gisela, Dirksen Robert T, Kinnally Kathleen W, Sheu Shey-Shing (2010) FEBS Lett
Abstract: Ca(2+) channels that underlie mitochondrial Ca(2+) transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca(2+) uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca(2+) transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca(2+) overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca(2+) channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca(2+) channels.
Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
• Bioblast editor: Cecatto C
Labels:
Regulation: Calcium, Ion;substrate transport
MitoFit 2022 CaG
