S/NS pathway control ratio

high-resolution terminology - matching measurements at high-resolution

S/NS pathway control ratio

Description

The CII/CI&II substrate control ratio is obtained when rotenone (Rot) is added to CI&II-linked respiration in a defined coupling state. The reversed protocol, adding CI-linked substrates to a CII-linked background state does not provide a valid estimation of CII-linked respiration with succinate in the absence of Rot, since oxaloacetate accumulates as a potent inhibitor of succinate dehydrogenase (CII).

Abbreviation: CII/CI&II

Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2014 MitoPathways

MitoPedia concepts: Respiratory control ratio