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| {{MitoPedia
| | #REDIRECT [[Succinate pathway]] |
| |abbr=S(Rot)
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| |description='''S(Rot)''': [[Succinate]] supports electron flux through CII via flavin adenine dinucleotide (FADH2). After inhibition of CI by [[rotenone]], the NADH-linked dehydrogenases become inhibited by the redox shift from NAD+ to NADH (Fig. 4.1). Succinate dehydrogenase is activated by succinate and ATP, which explains in part the time-dependent increase of respiration in isolated mitochondria after addition of rotenone (first), succinate and ADP.
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| |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.1]]
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| {{MitoPedia methods}}
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| |mitopedia topic=Respiratory substrate-coupling state
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