Difference between revisions of "Sabia 2009 Am J Clin Nutr"
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{{Publication | {{Publication | ||
|title=Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A (2009) Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study. Am J Clin Nutr 89: 601-607. | |title=Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A (2009) Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study. Am J Clin Nutr 89: 601-607. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/19073790 ] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/19073790 PMID: 19073790 Open Access] | ||
|authors=Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A | |authors=Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A | ||
|year=2009 | |year=2009 | ||
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Long-term obesity and long-term underweight in adulthood are associated with lower cognitive scores in late midlife. Public health messages should promote a healthy weight at all ages. | Long-term obesity and long-term underweight in adulthood are associated with lower cognitive scores in late midlife. Public health messages should promote a healthy weight at all ages. | ||
|keywords=BMI | |keywords=BMI | ||
}} | }} | ||
{{Labeling}} | {{Labeling}} | ||
Revision as of 21:19, 17 December 2012
| Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A (2009) Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study. Am J Clin Nutr 89: 601-607. |
Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A (2009) Am J Clin Nutr
Abstract: BACKGROUND:
The extent to which cognition in late midlife is influenced by lifetime obesity is unclear.
OBJECTIVE:
We examined the association between body mass index (BMI) over the adult life course and cognition in late midlife and assessed the cumulative effects of obesity and underweight.
DESIGN:
Data from the Whitehall II Study were examined. BMI at 25 y (early adulthood) was self-reported at phase 1 and was measured in early midlife (mean age = 44 y; phase 1) and in late midlife (mean age = 61 y; phase 7). Cognition (n = 5131) was assessed in late midlife (phase 7) by using the Mini-Mental State Examination and tests of memory and executive function, all of which were standardized to T scores (mean +/- SD: 50 +/- 10).
RESULTS:
Both underweight and obesity were associated with lower cognition in late midlife and with early adulthood, early midlife, and late midlife measures of BMI. Being obese at 2 or 3 occasions was associated with lower Mini-Mental State Examination scores and scores of memory and executive function in analyses adjusted for age, sex, and education [difference (95% CI) in mean T scores compared with normal-weight group: -1.51 (-2.77, -0.25), -1.27 (-2.46, -0.07), and -1.35 (-2.45, -0.24), respectively]. Participants who were underweight at > or =2 occasions from early adulthood to late midlife had lower executive function [difference (95% CI) in mean T score: -4.57 (-6.94, -2.20)]. A large increase in BMI from early to late midlife was associated with lower executive function.
CONCLUSIONS:
Long-term obesity and long-term underweight in adulthood are associated with lower cognitive scores in late midlife. Public health messages should promote a healthy weight at all ages. • Keywords: BMI
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