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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMitoEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0A-0AA-20wide-20spanersity-20of-20substrate-2Duncoupler-2Dinhibitor-20titration-20(SUIT)-20protocols-20has-20been-20used-20for-20evaluation-20of-20mitochondrial-20respiration-20in-20different-20samples-20and-20under-20various-20experimental-20conditions-20-5B1-5D.-20We-20developed-20a-20SUIT-20reference-20protocol-20(RP)-20with-20the-20goal-20to-20provide-20a-20common-20reference-20for-20establishing-20a-20database-20on-20comparative-20mitochondrial-20physiology-20-5B2-5D.-20The-20SUIT-2DRP-20consists-20of-20two-20complementary-20SUIT-20protocols:-20SUIT-2DRP1-20-5B3-5D-20and-20SUIT-2DRP2-20-5B4-5D.-20These-20protocols-20comprise-20specific-20respiratory-20pathways-20(FNSGp)-20converging-20at-20the-20Q-2Djunction-20(Figure-201).-20RP1-20and-20RP2-20are-20harmonized-20by-20inclusion-20of-20two-20comparable-20respiratory-20states-20(SGp-3Csub-3E-27-27E-27-27-3C-2Fsub-3E-20and-20CIV-3Csub-3E-27-27E-27-27-3C-2Fsub-3E).-20Harmonized-20states-20differ-20in-20terms-20of-20the-20sequence-20of-20substrate,-20uncoupler-20and-20inhibitor-20titrations-20(Figure-202).-20RP1-20includes-20respiratory-20states-20that-20can-20be-20compared-20to-20many-20previously-20published-20SUIT-20protocols.-20In-20the-20present-20communication,-20we-20address-20specifically-20the-20following-20topics:-20Are-20ET-20capacities-20identical-20in-20the-20harmonized-20states-20of-20RP1-20and-20RP2-20applied-20in-20parallel-20experiments-3F-20In-20our-20updated-20‘final’-20version-20of-20RP2,-20the-20sequence-20and-20concentrations-20of-20malate-20titrations-20was-20optimized-20to-20distinguish-20fatty-20acid-20oxidation-20capacity-20from-20the-20N-2Dpathway-20capacity.-20The-20harmonized-20respiratory-20states-20were-20in-20excellent-20agreement-20in-20a-20parallel-20experimental-20design-20with-20RP1-20and-20RP2-20(test-20and-20‘final’)-20applied-20to-20(i)-20isolated-20mouse-20cardiac-20mitochondria,-20(ii)-20brain-20tissue-20homogenate-20from-20mice,-20and-20(iii)-20cryopreserved-20permeabilized-20HEK-20cells-20-5B5-5D.-20On-20the-20other-20hand,-20previous-20studies-20demonstrate-20-5B6-5D-20that-20N-20pathway-20cannot-20be-20fully-20isolated-20from-20S-20pathway.-20S-2Dcontribution-20in-20SUIT-20protocols-20depends-20on-20the-20N-2Dsubstrate-20combinations-20used.-20We-20tested-20S-2Dcontribution-20in-20RP1-20and-20RP2-20protocols-20for-20a-20better-20understanding-20of-20bioenergetic-20complexity-20in-20mitochondrial-20physiology.-20In-20conclusion,-20an-20optimal-20design-20and-20comprehension-20of-20the-20SUIT-20protocols-20is-20crucial-20for-20a-20proper-20evaluation-20of-20mitochondrial-20function-20in-20healthy-20and-20pathological-20conditions." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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