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Property "Has-20abstract" (as page type) with input value "Adult-20cardiomyocytes-20have-20highly-20organized-20intracellular-20structure-20and-20energy-20metabolism-20whose-20formation-20during-20postnatal-20development-20is-20still-20largely-20unclear.-20Our-20previous-20results-20together-20with-20the-20data-20from-20the-20literature-20suggest-20that-20cytoskeletal-20proteins,-20particularly-20βII-2Dtubulin,-20are-20involved-20in-20the-20formation-20of-20complexes-20between-20mitochondria-20and-20energy-20consumption-20sites.-20The-20aim-20of-20this-20study-20was-20to-20examine-20the-20arrangement-20of-20intracellular-20architecture-20parallel-20to-20the-20alterations-20in-20regulation-20of-20mitochondrial-20respiration-20in-20rat-20cardiomyocytes-20during-20postnatal-20development,-20from-201day-20to-206months.-20Respirometric-20measurements-20were-20performed-20to-20study-20the-20developmental-20alterations-20of-20mitochondrial-20function.-20Changes-20in-20the-20mitochondrial-20arrangement-20and-20cytoarchitecture-20of-20βII-2D-20and-20αIV-2Dtubulin-20were-20examined-20by-20confocal-20microscopy.-20Our-20results-20show-20that-20functional-20maturation-20of-20oxidative-20phosphorylation-20in-20mitochondria-20is-20completed-20much-20earlier-20than-20efficient-20feedback-20regulation-20is-20established-20between-20mitochondria-20and-20ATPases-20via-20creatine-20kinase-20system.-20These-20changes-20are-20accompanied-20by-20significant-20remodeling-20of-20regular-20intermyofibrillar-20mitochondrial-20arrays-20aligned-20along-20the-20bundles-20of-20βII-2Dtubulin.-20Additionally,-20we-20demonstrate-20that-20formation-20of-20regular-20arrangement-20of-20mitochondria-20is-20not-20sufficient-20per-20se-20to-20provide-20adult-2Dlike-20efficiency-20in-20metabolic-20feed-2Dback-20regulation,-20but-20organized-20tubulin-20networks-20and-20reduction-20in-20mitochondrial-20outer-20membrane-20permeability-20for-20ADP-20are-20necessary-20as-20well.-20In-20conclusion,-20cardiomyocytes-20in-20rat-20heart-20become-20mature-20on-20the-20level-20of-20intracellular-20architecture-20and-20energy-20metabolism-20at-20the-20age-20of-203months." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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