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Property "Has-20abstract" (as page type) with input value "Caloric-20restriction-20(CR)-20protects-20against-20many-20cerebral-20pathological-20conditions-20that-20are-20associated-20with-20excitotoxic-20damage-20and-20calcium-20overload,-20although-20the-20mechanisms-20are-20still-20poorly-20understood.-20Here-20we-20show-20that-20CR-20strongly-20protects-20against-20excitotoxic-20insults-20-27-27in-20vitro-27-27-20and-20-27-27in-20vivo-27-27-20in-20a-20manner-20associated-20with-20significant-20changes-20in-20mitochondrial-20function.-20CR-20increases-20electron-20transport-20chain-20activity,-20enhances-20antioxidant-20defenses,-20and-20favors-20mitochondrial-20calcium-20retention-20capacity-20in-20the-20brain.-20These-20changes-20are-20accompanied-20by-20a-20decrease-20in-20cyclophilin-20D-20activity-20and-20acetylation-20and-20an-20increase-20in-20Sirt3-20expression.-20This-20suggests-20that-20Sirt3-2Dmediated-20deacetylation-20and-20inhibition-20of-20cyclophilin-20D-20in-20CR-20promote-20the-20inhibition-20of-20mitochondrial-20permeability-20transition,-20resulting-20in-20enhanced-20mitochondrial-20calcium-20retention.-20Altogether,-20our-20results-20indicate-20that-20enhanced-20mitochondrial-20calcium-20retention-20capacity-20underlies-20the-20beneficial-20effects-20of-20CR-20against-20excitotoxic-20conditions.-20This-20protection-20may-20explain-20the-20many-20beneficial-20effects-20of-20CR-20in-20the-20aging-20brain.-0A-0A©-202016-20The-20Authors.-20Aging-20Cell-20published-20by-20the-20Anatomical-20Society-20and-20John-20Wiley-20-26-20Sons-20Ltd." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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