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Property "Has-20abstract" (as page type) with input value "Glucocorticoids-20are-20used-20in-20the-20therapy-20of-20acute-20lymphoid-20leukemia-20(ALL)-20as-20well-20as-20and-20other-20lymphoid-20malignancies.-20An-20initial-20insufficient-20response-20to-20glucocorticoids-20has-20been-20shown-20to-20be-20an-20important-20prognostic-20marker-20for-20a-20bad-20outcome.-0A-0A2-2DDeoxy-2Dglucose-20(2-2DDG)-20is-20a-20glucose-20analog-20which-20is-20not-20metabolized-20and-20sensitizes-20ALL-2Dcells-20to-20non-2Dtoxic-20doses-20of-20glucocorticoids-20and-20resistant-20cells-20to-20glucocorticoids.-20However,-20the-20underlying-20molecular-20mechanism-20of-20glucocorticoid-2Dinduced-20cell-20death-20and-20the-20synergism-20with-202-2DDG-20remains-20poorly-20understood.-0A-0APrior-20work-20has-20shown-20a-20downregulation-20of-20the-20mitochondrial-20glutamate-2FH+-2Dsymporter-20(SLC25A22)-20and-20the-20mitochondrial-20dicarboxylate-20carrier-20(SLC25A10)-20in-20response-20to-20treatment-20with-20the-20glucocorticoid-20dexamethasone-20(DEX).-20Here-20I-20analyze-20the-20microsomal-20fraction-20of-20treated-20leukemic-20cells-20with-20a-20proteomic-20approach-20to-20further-20elucidate-20the-20mechanism.-0A-0AI-20show-20that-20treatment-20with-202-2DDG-20alone-20and-20in-20combination-20with-20DEX-20leads-20to-20increased-20expression-20of-20NMT-2D1,-20which-20has-20been-20implicated-20in-20the-20induction-20of-20apoptosis,-20and-20a-20reduction-20of-20HADH,-20an-20enzyme-20of-20beta-2Doxidation.-0A-0AI-20also-20show-20that-20inhibition-20of-20glycolysis-20by-202-2DDG-20is-20associated-20with-20downregulation-20of-20VDAC1.-20No-20synergistic-20effect-20with-20DEX-20can-20be-20shown.-0A-0AThe-20mechanism-20of-20synergy-20between-202-2DDG-20and-20glucocorticoids-20remains-20unclear." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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