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Property "Has-20abstract" (as page type) with input value "Mitochondrial-20involvement-20plays-20an-20important-20role-20in-20neurodegenerative-20diseases.-20At-20least-20one-2Dthird-20of-20adult-20carriers-20of-20a-20-27-27FMR1-27-27-20premutation-20(55-2D200-20CGG-20repeats)-20are-20at-20risk-20of-20presenting-20an-20adult-2Donset-20neurodegenerative-20disorder-20known-20as-20fragile-20X-2Dassociated-20tremor-2Fataxia-20syndrome-20(FXTAS).-20In-20an-20attempt-20to-20provide-20new-20insights-20into-20the-20mechanisms-20involved-20in-20the-20pathogenesis-20of-20FXTAS,-20we-20characterized-20mitochondrial-20function-20and-20dynamics-20by-20the-20assessment-20of-20oxidative-20respiratory-20chain-20function,-20mitochondrial-20content,-20oxidative-20stress-20levels,-20and-20mitochondrial-20network-20complexity.-20Regarding-20mitochondrial-20function,-20we-20found-20that-20mitochondrial-20respiratory-20capacity-20is-20compromised-20in-20skin-20fibroblasts-20whereas-20in-20blood,-20no-20differences-20were-20observed-20between-20the-20FXTAS-20and-20control-20groups.-20Furthermore,-20fibroblasts-20from-20FXTAS-20patients-20presented-20altered-20mitochondrial-20architecture,-20with-20more-20circular-20and-20less-20interconnected-20mitochondria-20being-20observed.-20Mitochondrial-20function-20and-20dynamics-20deregulation-20and-20characteristic-20of-20neurological-20disorders-20are-20present-20in-20FXTAS-20patients.-20These-20features-20might-20be-20limiting-20temporal-20and-20spatial-20bioenergetics-20cells-20supply-20and-20thus-20contributing-20to-20disease-20pathogenesis." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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