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Property "Has-20abstract" (as page type) with input value "Most-20mitochondrial-20proteins-20are-20encoded-20in-20the-20nucleus,-20and-20need-20to-20be-20imported-20into-20this-20organelle.-20The-20predominating,-20textbooks-20model-20for-20targeting-20to-20mitochondria-20asserts-20that-20proteins-20are-20translated-20throughout-20the-20cytoplasm-20and-20transported-20after-20their-20complete-20synthesis-20(i.e.-20post-2Dtranslationally).-20However,-20recent-20mRNA-20localization-20studies-20revealed-20that-20many-20mRNAs-20that-20encode-20mitochondrial-20proteins-20are-20localized-20to-20the-20vicinity-20of-20mitochondria-20in-20a-20manner-20that-20involves-20translation.-20These-20results-20revived-20neglected-20model-20in-20which-20translation-20of-20mitochondrial-20mRNAs-20is-20localized-20to-20the-20mitochondria-20vicinity-20and-20import-20occurs-20cotranslationally.-20We-20are-20exploring-20the-20proteins-20that-20coordinate-20such-20localized-20translation.-20We-20previously-20established-20the-20involvement-20of-20the-20mitochondrial-20protein-20receptor-20Tom20-20and-20the-20Hsp70-2Dmember-20Ssa1-20in-20association-20of-20translating-20ribosomes-20with-20the-20mitochondria-20-5B1,2-5D.-20-0AHerein-20we-20further-20elaborate-20on-20a-20role-20in-20localized-20translation-20for-20an-20additional-20factor,-20the-20conserved-20ribosome-2Dassociated-20Nascent-2Dchain-20Associated-20Complex-20(NAC).-20NAC-20was-20shown-20to-20contribute-20to-20ribosomes’-20association-20with-20mitochondria,-20yet-20its-20mitochondrial-20receptor-20was-20unknown.-20We-20performed-20several-20genome-2Dwide-20protein-20complementation-20assays-20and-20detected-20an-20outer-20membrane-20protein-20(OM14)-20of-20an-20unknown-20function-20as-20associated-20with-20NAC-5B3-5D.-20Mitochondria-20deleted-20of-20OM14-20had-20significantly-20lower-20amounts-20of-20associated-20NAC,-20and-20ribosomes-20deleted-20of-20NAC-20had-20reduced-20levels-20of-20associated-20OM14.-20Importantly,-20mitochondrial-20import-20assays-20revealed-20a-20significant-20decrease-20in-20import-20efficiency-20into-20OM14-20deleted-20mitochondria-20and-20OM14-2Ddependent-20import-20necessitated-20NAC.-20-0A-0AOur-20results-20identify-20OM14-20as-20a-20mitochondrial-20receptor-20for-20ribosomes-2Dassociated-20NAC-20and-20reveal-20its-20importance-20for-20import.-20These-20studies-20re-2Destablish-20localized-20translation-20as-20an-20additional-20mode-20for-20protein-20targeting-20to-20mitochondria." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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