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Property "Has-20abstract" (as page type) with input value "Novel-20therapies-20are-20needed-20for-20treating-20the-20increasing-20prevalence-20of-20hepatic-20steatosis-20in-20western-20populations.-20In-20this-20regard,-20dipeptidyl-20peptidase-2D4-20(DPP-2D4)-20inhibitors-20have-20recently-20been-20reported-20to-20attenuate-20the-20development-20of-20hepatic-20steatosis,-20but-20the-20potential-20mechanisms-20remain-20poorly-20defined.-20In-20the-20current-20study,-20four-20week-20old-20C57Bl-2F6-20mice-20were-20fed-20a-20high-20fat-2Fhigh-20fructose-20western-20diet-20(WD)-20or-20WD-20containing-20DPP-2D4-20inhibitor,-20MK0626,-20for-2016-20weeks.-20The-20DPP-2D4-20inhibitor-20prevented-20WD-2Dinduced-20hepatic-20steatosis-20and-20reduced-20hepatic-20insulin-20resistance-20by-20enhancing-20insulin-20suppression-20of-20hepatic-20glucose-20output.-20WD-2Dinduced-20accumulation-20of-20hepatic-20triacylglycerol-20(TAG)-20and-20diacylglycerol-20(DAG)-20content-20was-20significantly-20attenuated-20with-20DPP-2D4-20inhibitor-20treatment.-20In-20addition,-20MK0626-20significantly-20reduced-20mitochondrial-20incomplete-20palmitate-20oxidation-20and-20increased-20indices-20of-20pyruvate-20dehydrogenase-20activity,-20TCA-20cycle-20flux,-20and-20hepatic-20TAG-20secretion.-20Furthermore,-20DPP4-2Dinhibition-20rescued-20WD-2Dinduced-20decreases-20in-20hepatic-20PGC-2D1α-20and-20CPT-2D1-20mRNA-20expression-20and-20hepatic-20Sirt1-20protein-20content.-20Moreover,-20plasma-20uric-20acid-20levels-20in-20WD-20fed-20mice-20were-20decreased-20after-20MK0626-20treatment.-20These-20studies-20suggest-20that-20DPP-2D4-20inhibition-20ameliorates-20hepatic-20steatosis-20and-20insulin-20resistance-20by-20suppressing-20hepatic-20TAG-20and-20DAG-20accumulation-20through-20enhanced-20mitochondrial-20carbohydrate-20utilization-20and-20hepatic-20TAG-20secretion-2Fexport-20with-20concomitant-20reduction-20of-20uric-20acid-20production." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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