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Property "Has-20abstract" (as page type) with input value "Our-20laboratory-20has-20previously-20demonstrated-20the-20presence-20of-20constitutively-20expressed-20mitochondrial-20uncoupling-20protein-201-20in-20mouse-20thymocytes.-20In-20our-20endeavours-20to-20understand-20the-20role-20of-20mitochondrial-20uncoupling-20protein-201-20in-20thymocyte-20function,-20we-20compared-20cell-20profiles-20in-20thymus-20and-20spleen-20of-20wild-2Dtype-0Awith-20those-20of-20UCP-201-20knock-2Dout-20mice,-20which-20in-20turn-20led-20to-20comparative-20investigations-20of-20apoptotic-20potential-20in-20thymocytes-20from-20these-20mice.-20We-20demonstrate-20that-20spleen-20cell-20numbers-20were-20reduced-20∼3-2Dfold-20in-20UCP-201-20knock-2Dout-20mice-20compared-20to-20wild-2Dtype-20mice.-20We-20record-20a-20halving-20of-20CD8-20single-20positive-20cell-20numbers-20in-20thymus-20with-20a-20significant-20incremental-20increase-20in-20CD4-2FCD8-20double-20positives-20cell-20numbers-20in-20the-20thymus-20of-20UCP-201-20knock-2Dout-20mice-20compared-20to-20wild-2Dtype-20mice.-20These-20data-20are-20mirrored-20by-20an-20approximate-20halving-20of-20CD8-20single-20positive-20cell-20numbers-20and-20a-20doubling-20of-20CD4-2FCD8-20double-20positive-20cell-20numbers-20in-20the-20spleen-20of-20UCP-201-20knock-2Dout-20mice-20compared-20to-20wild-2Dtype-20mice.-20These-20differences-20are-20most-20probably-20explained-20by-20our-20observations-20of-20decreased-20apoptotic-20potential-20and-20higher-20ATP-20levels-20in-20thymocytes-20of-20UCP-201-20knock-2Dout-20mice-0Awhen-20compared-20to-20wild-2Dtype-20controls.-20We-20conclude-20that-20constitutively-20expressed-20UCP-201-20is-20a-20factor-20in-20determining-20T-2Dcell-20population-20selection-20in-20mice." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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