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Property "Has-20abstract" (as page type) with input value "Statin-20myopathy-20is-20linked-20to-20disturbances-20in-20mitochondrial-20function-20and-20exercise-20intolerance.-0A-0ATo-20determine-20whether-20differences-20exist-20in-20exercise-20performance,-20muscle-20function,-20and-20muscle-20mitochondrial-20oxidative-20capacity-20and-20content-20between-20symptomatic-20and-20asymptomatic-20statin-20users,-20and-20control-20subjects.-0A-0ACross-2Dsectional-20study.-0A-0ADepartment-20of-20Physiology,-20Radboud-20University-20Medical-20Center.-0A-0ALong-2Dterm-20symptomatic-20and-20asymptomatic-20statin-20users,-20and-20control-20subjects-20(n-20=-2010-20per-20group).-0A-0AMaximal-20incremental-20cycling-20tests,-20involuntary-20electrically-20stimulated-20isometric-20quadriceps-2Dmuscle-20contractions,-20and-20biopsy-20of-20vastus-20lateralis-20muscle.-0A-0AMaximal-20exercise-20capacity,-20substrate-20use-20during-20exercise,-20muscle-20function,-20and-20mitochondrial-20energy-20metabolism.-0A-0APeak-20oxygen-20uptake,-20maximal-20work-20load,-20and-20ventilatory-20efficiency-20were-20comparable-20between-20groups,-20but-20both-20statin-20groups-20had-20a-20depressed-20anaerobic-20threshold-20compared-20with-20the-20control-20group-20(P-20=-200.01).-20Muscle-20relaxation-20time-20was-20prolonged-20in-20both-20statin-20groups-20compared-20with-20the-20control-20group-20and-20rate-20of-20maximal-20force-20rise-20was-20decreased-20(P-3Csub-3Etime×group-3C-2Fsub-3E-20-3C-200.001-20for-20both-20measures).-20Mitochondrial-20activity-20of-20complexes-20II-20and-20IV-20was-20lower-20in-20symptomatic-20statin-20users-20than-20control-20subjects-20and-20tended-20to-20be-20lower-20for-20complex-20(C)-20III-20(CII:-20P-20=-200.03-3B-20CIII:-20P-20=-200.05-3B-20CIV:-20P-20=-200.04).-20Mitochondrial-20content-20tended-20to-20be-20lower-20in-20both-20statin-20groups-20than-20in-20control-20subjects.-0A-0AStatin-20use-20attenuated-20substrate-20use-20during-20maximal-20exercise-20performance,-20induced-20muscle-20fatigue-20during-20repeated-20muscle-20contractions,-20and-20decreased-20muscle-20mitochondrial-20oxidative-20capacity.-20This-20suggests-20disturbances-20in-20mitochondrial-20oxidative-20capacity-20occur-20with-20statin-20use-20even-20in-20patients-20without-20statin-2Dinduced-20muscle-20complaints." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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