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Property "Has-20abstract" (as page type) with input value "The-20combined-20loss-20of-20muscle-20strength-20and-20constant-20fatigue-20are-20disabling-20symptoms-20for-20cancer-20patients-20undergoing-20chemotherapy.-20Doxorubicin,-20a-20standard-20chemotherapy-20drug-20used-20in-20the-20clinic,-20causes-20skeletal-20muscle-20dysfunction-20and-20premature-20fatigue-20along-20with-20an-20increase-20in-20reactive-20oxygen-20species-20(ROS).-20As-20mitochondria-20represent-20a-20primary-20source-20of-20oxidant-20generation-20in-20muscle,-20we-20hypothesized-20that-20doxorubicin-20could-20negatively-20affect-20mitochondria-20by-20inhibiting-20respiratory-20capacity,-20leading-20to-20an-20increase-20in-20H2O2-2Demitting-20potential.-20Here-20we-20demonstrate-20a-20biphasic-20response-20of-20skeletal-20muscle-20mitochondria-20to-20a-20single-20doxorubicin-20injection-20(20-20mg-2Fkg).-20Initially-20at-202-20h-20doxorubicin-20inhibits-20both-20Complex-20I-2D-20and-20II-2Dsupported-20respiration-20and-20increases-20H2O2-20emission,-20both-20of-20which-20are-20partially-20restored-20after-2024-20h.-20The-20relationship-20between-20oxygen-20consumption-20and-20membrane-20potential-20(Δ-27-27Ψ-27-27(mt))-20is-20shifted-20to-20the-20right-20at-2024-20h,-20indicating-20elevated-20reducing-20pressure-20within-20the-20electron-20transfer-2Dpathway-20(ET-2Dpathway).-20Respiratory-20capacity-20is-20further-20decreased-20at-20a-20later-20time-20point-20(72-20h)-20along-20with-20H2O2-2Demitting-20potential-20and-20an-20increased-20sensitivity-20to-20mitochondrial-20permeability-20transition-20pore-20(mtPTP)-20opening.-20These-20novel-20findings-20suggest-20a-20role-20for-20skeletal-20muscle-20mitochondria-20as-20a-20potential-20underlying-20cause-20of-20doxorubicin-2Dinduced-20muscle-20dysfunction." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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