Difference between revisions of "Succinate and rotenone"
| Line 1: | Line 1: | ||
{{MitoPedia | {{MitoPedia | ||
|abbr=S | |abbr=S(Rot) | ||
|description=Inhibition of [[Complex I]] by [[rotenone]] (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | |description=Substrate supply by '''succinate''' (S) is the basis for electron input through Complex II into the [[mETS]]. Inhibition of [[Complex I]] by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of [[succinate dehydrogenase]]. | ||
|info=MiPNet11.09, MiPNet12.11 | |info=[[MiPNet11.09]], [[MiPNet12.11]] | ||
|type=Substrate ETS | |type=Substrate ETS | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
|enzymes=Complex II; Succinate Dehydrogenase | |enzymes=Complex II; Succinate Dehydrogenase | ||
|kinetics=Inhibitor; Uncoupler | |||
|topics=Respiration; OXPHOS; ETS Capacity, Substrate; Glucose; TCA Cycle | |||
|type=Substrate ETS | |||
}} | }} | ||
Revision as of 14:52, 21 October 2010
- high-resolution terminology - matching measurements at high-resolution
Succinate and rotenone
Description
Substrate supply by succinate (S) is the basis for electron input through Complex II into the mETS. Inhibition of Complex I by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase.
Abbreviation: S(Rot)
Reference: MiPNet11.09, MiPNet12.11
Labels:
Enzyme: Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
