Difference between revisions of "Uncoupler"
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An uncoupler | {{MitoPedia | ||
|abbr=u | |||
|description=An '''uncoupler''' is a protonophore (FCCP, CCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. | |||
{{ | |type=Chemicals | ||
}} | |||
{{Labeling | |||
|kinetics=Inhibitor; Uncoupler | |||
}} | |||
Revision as of 10:13, 14 September 2010
- high-resolution terminology - matching measurements at high-resolution
Uncoupler
Description
An uncoupler is a protonophore (FCCP, CCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed.
Abbreviation: u
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