Difference between revisions of "Wang 2018 Mol Med Rep"
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|title=Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. | |title=Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. https://doi.org/10.3892/mmr.2018.9619 | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/30387826 PMID: 30387826 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/30387826 PMID: 30387826 Open Access] | ||
|authors=Wang B, Li W, Fang H, Zhou H | |authors=Wang B, Li W, Fang H, Zhou H | ||
|year=2018 | |year=2018 |
Latest revision as of 16:42, 19 July 2022
Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. https://doi.org/10.3892/mmr.2018.9619 |
Wang B, Li W, Fang H, Zhou H (2018) Mol Med Rep
Abstract: Chronic hepatitis B virus (HBV) infection has been reported to be associated with the prevalence of nonâalcoholic fatty liver disease (NAFLD). However, the present study demonstrated that the incidence of fatty liver disease in HBVâinfected subjects (16/152, 10.5%) was not significantly different from in nonâHBVâinfected subjects (292/1,714, 17%), following adjustment for age (odds ratio=0.656; 95% confidence interval=0.379â1.134; P=0.131). Hepatitis B protein X (HBx) is considered a key regulator in HBV infection and several studies have confirmed that HBx serves a pivotal role in the process of fatty liver disease. In the present study, it was demonstrated that HBxâexpressing cells exhibited increased mitochondrial membrane potential, ATP generation, and endogenous mitochondrial respiration. In addition, higher levels of mitochondrial reactive oxygen species (ROS) were detected in HBxâexpressing cells compared with in control cells. Increased ROS production may contribute to increased lipid droplet formation in HBxâexpressing cells, whereas the removal of ROS with Nâacetylcysteine may decrease the accumulation of lipid droplets in a timeâdependent manner. In conclusion, the present findings indicated that HBV, and perhaps more specifically HBx, was not a protective factor against NAFLD. HBx may function as a risk factor for fatty liver disease, based on the findings of the present functional study; however, further studies are required to clarify the effects of HBx on hepatic steatosis. âą Keywords: Hepatitis B virus/hepatitis B protein X, Fatty liver disease, Nonâalcoholic fatty liver disease, Reactive oxygen species, Lipid droplet âą Bioblast editor: Plangger M
Labels: MiParea: Respiration, mt-Medicine
Pathology: Infectious
Organism: Human Tissue;cell: Liver Preparation: Intact cells
Coupling state: LEAK, ET
HRR: Oxygraph-2k
Labels, 2018-11, Virus