Difference between revisions of "Xue 2019 Sci Rep"
(Created page with "{{Publication |title=Xue YP, Kao MC, Lan CY (2019) Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity. Sci Rep 9:13694. |info=[https://www....") Β |
|||
Line 10: | Line 10: | ||
{{Labeling | {{Labeling | ||
|area=Respiration, Pharmacology;toxicology | |area=Respiration, Pharmacology;toxicology | ||
|organism=Fungi | |||
|preparations=Intact cells | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Labels, 2019-10, | |additional=Labels, 2019-10, | ||
}} | }} |
Revision as of 14:10, 8 October 2019
Xue YP, Kao MC, Lan CY (2019) Novel mitochondrial complex I-inhibiting peptides restrain NADH dehydrogenase activity. Sci Rep 9:13694. |
Xue YP, Kao MC, Lan CY (2019) Sci Rep
Abstract: The emergence of drug-resistant fungal pathogens is becoming increasingly serious due to overuse of antifungals. Antimicrobial peptides have potent activity against a broad spectrum of pathogens, including fungi, and are considered a potential new class of antifungals. In this study, we examined the activities of the newly designed peptides P-113Du and P-113Tri, together with their parental peptide P-113, against the human fungal pathogen Candida albicans. The results showed that these peptides inhibit mitochondrial complex I, specifically NADH dehydrogenase, of the electron transport chain. Moreover, P-113Du and P-113Tri also block alternative NADH dehydrogenases. Currently, most inhibitors of the mitochondrial complex I are small molecules or artificially-designed antibodies. Here, we demonstrated novel functions of antimicrobial peptides in inhibiting the mitochondrial complex I of C. albicans, providing insight in the development of new antifungal agents.
β’ Bioblast editor: Plangger M
Labels: MiParea: Respiration, Pharmacology;toxicology
Organism: Fungi
Preparation: Intact cells
HRR: Oxygraph-2k
Labels, 2019-10