Difference between revisions of "Yin 2022 J Exp Med"
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|title=Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z (2022) FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. https://doi.org/10.1084/jem.20212491 | |title=Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z (2022) FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. https://doi.org/10.1084/jem.20212491 | ||
|info=J Exp Med 219:e20212491. [https://pubmed.ncbi.nlm.nih.gov/35412553 PMID: 35412553 Open Access] | |info=J Exp Med 219:e20212491. [https://pubmed.ncbi.nlm.nih.gov/35412553 PMID: 35412553 Open Access] | ||
|authors= | |authors=Yin Yujing, Xu Dengqiu, Mao Yan, Xiao Liwei, Sun Zongchao, Liu Jing, Zhou Danxia, Xu Zhisheng, Liu Lin, Fu Tingting, Ding Chenyun, Guo Qiqi, Sun Wanping, Zhou Zheng, Yang Likun, Jia Yuhuan, Chen Xinyi, Gan Zhenji | ||
|year=2022 | |year=2022 | ||
|journal=J Exp Med | |journal=J Exp Med | ||
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|tissues=Fat | |tissues=Fat | ||
|preparations=Permeabilized cells | |preparations=Permeabilized cells | ||
|topics=Calcium | |||
|couplingstates=LEAK, OXPHOS | |couplingstates=LEAK, OXPHOS | ||
|pathways=F, N, S, ROX | |pathways=F, N, S, ROX | ||
Revision as of 16:14, 30 November 2022
| Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z (2022) FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. https://doi.org/10.1084/jem.20212491 |
» J Exp Med 219:e20212491. PMID: 35412553 Open Access
Yin Yujing, Xu Dengqiu, Mao Yan, Xiao Liwei, Sun Zongchao, Liu Jing, Zhou Danxia, Xu Zhisheng, Liu Lin, Fu Tingting, Ding Chenyun, Guo Qiqi, Sun Wanping, Zhou Zheng, Yang Likun, Jia Yuhuan, Chen Xinyi, Gan Zhenji (2022) J Exp Med
Abstract: Metabolically beneficial beige adipocytes offer tremendous potential to combat metabolic diseases. The folliculin interacting protein 1 (FNIP1) is implicated in controlling cellular metabolism via AMPK and mTORC1. However, whether and how FNIP1 regulates adipocyte browning is unclear. Here, we demonstrate that FNIP1 plays a critical role in controlling adipocyte browning and systemic glucose homeostasis. Adipocyte-specific ablation of FNIP1 promotes a broad thermogenic remodeling of adipocytes, including increased UCP1 levels, high mitochondrial content, and augmented capacity for mitochondrial respiration. Mechanistically, FNIP1 binds to and promotes the activity of SERCA, a main Ca2+ pump responsible for cytosolic Ca2+ removal. Loss of FNIP1 resulted in enhanced intracellular Ca2+ signals and consequential activation of Ca2+-dependent thermogenic program in adipocytes. Furthermore, mice lacking adipocyte FNIP1 were protected against high-fat diet-induced insulin resistance and liver steatosis. Thus, these findings reveal a pivotal role of FNIP1 as a negative regulator of beige adipocyte thermogenesis and unravel an intriguing functional link between intracellular Ca2+ dynamics and adipocyte browning.
• Bioblast editor: Plangger M
Labels: MiParea: Respiration
Organism: Mouse
Tissue;cell: Fat
Preparation: Permeabilized cells
Regulation: Calcium Coupling state: LEAK, OXPHOS Pathway: F, N, S, ROX HRR: Oxygraph-2k
2022-11
