Zhang 2022 Ecotoxicol Environ Saf

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Zhang Y, Yuan F, Li P, Gu J, Han J, Ni Z, Liu F (2022) Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function. https://doi.org/10.1016/j.ecoenv.2022.113788

Β» Ecotoxicol Environ Saf 241:113788. PMID: 35738103 Open Access

Zhang Yuming, Yuan Fengyu, Li Pei, Gu Jihai, Han Junjun, Ni Zhihua, Liu Fengsong (2022) Ecotoxicol Environ Saf

Abstract: The beneficial roles of resveratrol (RES) in affecting proliferation of multiple cancer cells have attracted intensive attention. However, the underlying mechanism remains unclear. This study aims to bridge the knowledge gap by investigating RES-induced growth inhibition of HeLa cells. Our work focuses on the metergasis of mitochondria in the RES-exposed cells. Therefore, HeLa cells were treated with different concentrations of RES for 30 min and 24 h, respectively. As a result, concentration-dependent increases in cell growth inhibition, ROS (reactive oxygen species) triggering, and LC3-II (light chain 3-II) expression were detected in the HeLa cells exposed to RES for 24 h. Interestingly, a specific concentration-dependent effect was observed in the HeLa cells exposed to RES for 30 min, that is, low concentration RES (≀ 25 ΞΌmol/L) reduced ROS levels, inhibited transcription and expression levels of LC3-II, and stimulated mitochondrial respiratory capacities. In contrast, high concentration RES (50 and 100 ΞΌmol/L) induced ROS over-production and autophagy in the cells, resulting in decreased levels of mitochondrial membrane potential, mitochondrial DNA copy numbers, and mitochondrial respiratory capacities. Together, our data concluded that RES inhibited HeLa cell proliferation through perturbation of mitochondrial structure and function, and ROS-induced autophagy also played a critical role in the process. β€’ Keywords: Autophagy, Cell homeostasis, HeLa cells, Mitochondrial function, Resveratrol β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: CN Baoding Liu F

Labels: MiParea: Respiration, Pharmacology;toxicology 

Organism: Human  Tissue;cell: HeLa  Preparation: Intact cells 

Coupling state: LEAK, ROUTINE, ET  Pathway: ROX  HRR: Oxygraph-2k 

CN, 2022-10 

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