Difference between revisions of "NextGen-O2k H2020 SME Phase 1"
From Bioblast
Laner Verena (talk | contribs) m (Laner Verena moved page NextGen-O2k to NextGen-O2k H2020 SME Phase 1) |
|||
| Line 1: | Line 1: | ||
{{OROBOROS_header_page_name}} | |||
:::: <big><big>A project in progress</big></big> | |||
== Tyrolean Government grant == | |||
[[File:Sponsorlogo gefoerdert RGB.jpg|right|350px]] | |||
::::* The project '''NextGen-O2k''' is supported by the "'''Technologieförderungsprogramm - Tiroler Innovationsförderung'''" of the Tyrolean Government. | |||
::::* '''Project duration''': 2015-02-01 to 2017-01-31. | |||
::::* '''Partners''': [[About Oroboros]], [[Oroboros partners| WGT Elektronik]], [[Oroboros partners| software security networks]]. | |||
::::* '''Application''': 2015-01-30; '''Granted''': 2015-03-24 (total budget € 350.000). | |||
::::* Funding: '''€ 140,000''' plus a bonus of '''€ 5,000''' for the implementation of gender sensitive actions. | |||
== NextGen-O2k publication == | |||
::::* Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol Aug 6:jap.00146.2015. doi: 10.1152/japplphysiol.00146.2015. - [[Harrison_2015_J_Appl_Physiol |»Bioblast link«]] | |||
== The fourth dimension of respiratory control == | |||
::::# On the "line": one dimension is insufficient. | |||
::::# Coupling and pathway control are two necessarily connected dimensions defining the “area” of respiratory control. | |||
::::# Adding kinetics (including substrate kinetics of O<sub>2</sub>, CHO, adenylates, P<sub>i</sub>, and flux-force kinetics) is the third dimension bringing “volume” into the picture of classical mitochondrial respiratory control. | |||
::::# The NextGen-O2k on top of O2k-MultiSensor modules and the [[O2k-FluoRespirometer]] represent the fourth dimension of respiratory control, by adding analysis of functional variables (such as ROS production, mt-membrane potential, Ca<sup>2+</sup>, proton flux, cytochrome and NADH redox states, ATP production) to the measurement of O<sub>2</sub> and O<sub>2</sub>-flux in the same chamber. | |||
== Development of the NextGen-O2k: a look inside == | |||
:::: Different stages of prototype development: The [[NextGen-O2k description|NextGen-O2k]] is becoming more and more packed with two spectrofluorometers, two spectrophotometers, light guides, Peltier temperatue control with new heat pipes, microelectronics. | |||
<gallery mode=default perrow=2 widths="500px" heights="300px"> | |||
File:NextGen 1.JPG | |||
File:NextGen_2.JPG | |||
File:NextGen_4.JPG | |||
File:NextGen_5.JPG | |||
</gallery> | |||
Revision as of 14:42, 7 August 2018
NextGen-O2k H2020 SME Phase 1
- A project in progress
Tyrolean Government grant
- The project NextGen-O2k is supported by the "Technologieförderungsprogramm - Tiroler Innovationsförderung" of the Tyrolean Government.
- Project duration: 2015-02-01 to 2017-01-31.
- Partners: About Oroboros, WGT Elektronik, software security networks.
- Application: 2015-01-30; Granted: 2015-03-24 (total budget € 350.000).
- Funding: € 140,000 plus a bonus of € 5,000 for the implementation of gender sensitive actions.
NextGen-O2k publication
- Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol Aug 6:jap.00146.2015. doi: 10.1152/japplphysiol.00146.2015. - »Bioblast link«
The fourth dimension of respiratory control
- On the "line": one dimension is insufficient.
- Coupling and pathway control are two necessarily connected dimensions defining the “area” of respiratory control.
- Adding kinetics (including substrate kinetics of O2, CHO, adenylates, Pi, and flux-force kinetics) is the third dimension bringing “volume” into the picture of classical mitochondrial respiratory control.
- The NextGen-O2k on top of O2k-MultiSensor modules and the O2k-FluoRespirometer represent the fourth dimension of respiratory control, by adding analysis of functional variables (such as ROS production, mt-membrane potential, Ca2+, proton flux, cytochrome and NADH redox states, ATP production) to the measurement of O2 and O2-flux in the same chamber.
Development of the NextGen-O2k: a look inside
- Different stages of prototype development: The NextGen-O2k is becoming more and more packed with two spectrofluorometers, two spectrophotometers, light guides, Peltier temperatue control with new heat pipes, microelectronics.
