Brunetta 2023 MiP2023

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MiPschool 2023

Brunetta 2023 MiP2023

Brunetta Henver Simionato
Chronic aerobic training reverts the negative effects of high-fat high-sucrose diet on the left ventricle of adipocyte-specific DICER knockout mice in association with improved mitochondrial function

Link: MiP2023 Obergurgl AT

Brunetta Henver Simionato (2023)

Event: MiP2023 Obergurgl AT

Authors: Brunetta Henver Simionato, Palermo Ruiz Gabriel, Ludwig Raissa, Ruberti Olivia, Bechara Luiz, Consonni Silvio, Rodrigues Bruno, Ferreira Julio Cesar B, Mori Marcelo AS

The negative effects of high-fat high-sucrose (HFHS) diet consumption on heart function are exacerbated in mice lacking DICER in adipocytes (AdicerKO). These findings suggest a protective role of adipocyte-derived microRNAs on heart physiology. Exercise training is known to have a protective role in cardiometabolic diseases. However, it is not known whether chronic aerobic training is able to rescue heart dysfunction in HFHS-fed AdicerKO mice. Here, we fed AdicerKO mice with a HFHS diet for 12 weeks, after confirming the deleterious effects of the diet on these mice, we submitted them to moderate aerobic training for 8 weeks, 5 days/week for 60 minutes each section while keeping them on HFHS-diet. Chronic aerobic training restored end-systolic volume and stroke volume in the hearts of HFHS-fed AdicerKO mice without changing ejection fraction. In addition, aerobic exercise increased left ventricle diameter in both, systolic and diastolic, phases. Notably, HFHS-fed AdicerKO-trained mice presented lower heart rate with no differences in systolic blood pressure compared to HFHS-fed AdicerKO sedentary mice. Mechanistically, chronic exercise training lowered mitochondrial H2O2 emission and oxidative stress alongside greater lipid- and succinate-supported mitochondrial respiration. Importantly, these effects were not followed by changes in triacylglycerol content within the left ventricle or fibrosis. In summary, chronic aerobic training is capable to rescue heart function of HFHS-fed AdicerKO mice in association with improvements in mitochondrial bioenergetics and redox balance.

Labels: MiParea: Exercise physiology;nutrition;life style 

Organism: Mouse  Tissue;cell: Heart 

Event: Oral 


Henver S. Brunetta1,2, Gabriel Palermo Ruiz1,2, RaΓ­ssa Ludwig1,2, Olivia Ruberti2, Luiz Bechara3, Silvio Consonni2, Bruno Rodrigues2, Julio Ferreira3, Marcelo A. S. Mori1,2
  1. Laboratory of Aging Biology, University of Campinas, Campinas, Brazil
  2. University of Campinas, Campinas, Brazil
  3. University of SΓ£o Paulo, SΓ£o Paulo, Brazil
Corresponding author:
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