Complex II ambiguities

From Bioblast


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Complex II ambiguities

Description

CII-ambiguities Graphical abstract.png

The current narrative that the reduced coenzymes NADH and FADH2 feed electrons from the tricarboxylic acid (TCA) cycle into the mitochondrial electron transfer system can create ambiguities around respiratory Complex CII. Succinate dehydrogenase or CII reduces FAD to FADH2 in the canonical forward TCA cycle. However, some graphical representations of the membrane-bound electron transfer system (ETS) depict CII as the site of oxidation of FADH2. This leads to the false believe that FADH2 generated by electron transferring flavoprotein (CETF) in fatty acid oxidation and mitochondrial glycerophosphate dehydrogenase (CGpDH) feeds electrons into the ETS through CII. In reality, NADH and succinate produced in the TCA cycle are the substrates of Complexes CI and CII, respectively, and the reduced flavin groups FMNH2 and FADH2 are downstream products of CI and CII, respectively, carrying electrons from CI and CII into the Q-junction. Similarly, CETF and CGpDH feed electrons into the Q-junction but not through CII. The ambiguities surrounding Complex II in the literature call for quality control, to secure scientific standards in current communications on bioenergetics and support adequate clinical applications.

Abbreviation: CII ambiguities

Reference: Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300: 105470. https://doi.org/10.1016/j.jbc.2023.105470

» Links: Ambiguity crisis, Complex I and hydrogen ion ambiguities in the electron transfer system

A game of cards

33 copies or variations of a CII ambiguity theme
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Joshi 2022 Biomolecules CORRECTION.png
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Anoar 2021 Front Neurosci CORRECTION.jpg
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Vesga 2021 Med Chem Res CORRECTION.png
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Prasuhn 2021 Front Cell Dev Biol CORRECTION.png
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Yuan 2022 Oxid Med Cell Longev CORRECTION.png
32. Yuan Q, Zeng ZL, Yang S, Li A, Zu X, Liu J (2022) Mitochondrial stress in metabolic inflammation: modest benefits and full losses. Oxid Med Cell Longev 2022:8803404. - »Bioblast link«


Yin 2021 FASEB J CORRECTION.png
33. Yin M, O'Neill LAJ (2021) The role of the electron transport chain in immunity. FASEB J 35:e21974. - »Bioblast link«



Doubles

Chen 2014 Circ Res CORRECTION.png
1. Chen YR, Zweier JL (2014) Cardiac mitochondria and reactive oxygen species generation. Circ Res 114:524-37. - »Bioblast link«


Chen 2022 Am J Physiol Cell Physiol CORRECTION.png
2. Chen CL, Zhang L, Jin Z, Kasumov T, Chen YR (2022) Mitochondrial redox regulation and myocardial ischemia-reperfusion injury. Am J Physiol Cell Physiol 322:C12-23. - »Bioblast link«



Chen 2022 Int J Mol Sci CORRECTION.png
1. Chen TH, Koh KY, Lin KM, Chou CK (2022) Mitochondrial dysfunction as an underlying cause of skeletal muscle disorders. Int J Mol Sci 23:12926. - »Bioblast link«


Schniertshauer 2023 Curr Issues Mol Biol CORRECTION.jpg.png
2. Schniertshauer D, Wespel S, Bergemann J (2023) Natural mitochondria targeting substances and their effect on cellular antioxidant system as a potential benefit in mitochondrial medicine for prevention and remediation of mitochondrial dysfunctions. Curr Issues Mol Biol 45:3911-32. - »Bioblast link«



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