Glycerophosphate shuttle

From Bioblast

high-resolution terminology - matching measurements at high-resolution

Glycerophosphate shuttle



The glycerophosphate shuttle makes cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophosphate dehydrogenase. On the outer face of the inner mitochondrial membrane, glycerophosphate dehydrogenase complex (mitochondrial glycerophosphate dehydrogenase) oxidizes glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein transfers its reducing equivalents into the Q-junction, thus representing a ET pathway level 3 control state.

Abbreviation: Gp shuttle

Reference: Gnaiger 2020 BEC MitoPathways

MitoPedia topics: Enzyme 

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