Mitochondrial malate dehydrogenase is localized in the mitochondrial matrix and oxidizes malate, generated from fumarate by fumarase, to oxaloacetate, reducing NAD+ to NADH+H+ in the TCA cycle. Malate is added as a substrate in most N-pathway control states.
Reference: Gnaiger 2020 BEC MitoPathways
- Dasika SK, Vinnakota KC, Beard DA (2015) Determination of the catalytic mechanism for mitochondrial malate dehydrogenase. Biophys J 108:408-19. - »Bioblast link«
MitoPedia topics: Enzyme