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Aguirre 2012 Mitochondrion
Has abstract The possible existence of a mitochondriall
The possible existence of a mitochondrially localized nitric oxide (NO) synthase (mtNOS) is controversial. To clarify this, we studied the ability of intact mitochondria to generate NO and the effect of mitochondrial NO on respiration. Respiratory rates and oxygen kinetics (P(50) values) were determined by high-resolution respirometry in skeletal-muscle mitochondria from control mice and mice injected with Escherichia coli lipopolysaccharide (LPS). In the presence of the NOS substrate L-arginine, mitochondria from LPS-treated mice had lower respiration rates and higher P(50) values than control animals. These effects were prevented by the NOS inhibitor L-NMMA. Our results suggest that mitochondrially derived NO is generated by an LPS-inducible NOS protein other than iNOS and modulates oxygen consumption in mouse skeletal muscle.
ygen consumption in mouse skeletal muscle.  +
Has info [ PMID: 21664300]  +
Has publicationkeywords Nitric oxide (NO) synthase (mtNOS)  + , Respiratory rates and oxygen kinetics (P(50)  + , Escherichia coli lipopolysaccharide (LPS)  +
Has title Aguirre E, Lopez-Bernardo E, Cadenas S (2012) Functional evidence for nitric oxide production by skeletal-muscle mitochondria from lipopolysaccharide-treated mice. Mitochondrion 12:126-31.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
Preparation Isolated mitochondria  +
Stress Oxidative stress;RONS  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab ES Madrid Cadenas S +
Was published in journal Mitochondrion +
Was published in year 2012  +
Was written by Aguirre E + , Lopez-Bernardo E + , Cadenas S +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
13:43:20, 10 March 2015  +
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