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Albertini 2012 Aging (Albany NY)
Coupling states LEAK  + , ROUTINE  + , ET  +
Diseases Aging;senescence  +
Enzyme Complex I  + , Complex III  +
Has abstract Availability of methionine is known to mod
Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood. In eukaryotic cells, methionine can be converted to cysteine through the reverse transsulfuration pathway thereby modulating intracellular methionine availability. Whereas previous results obtained in yeast and fruit flies suggest that alterations in the reverse transsulfuration pathway modulate the rate of aging, it is not known whether this function is conserved in evolution. Here we show that depletion of cystathionine beta synthase (CBS), a rate limiting enzyme in the reverse transsulfuration pathway, induces premature senescence in human endothelial cells. We found that CBS depletion induces mild mitochondrial dysfunction and increases the sensitivity of endothelial cells to homocysteine, a known inducer of endothelial cell senescence and an established risk factor for vascular disease. Our finding that CBS deficiency induces endothelial cell senescence ''in vitro'', involving both mitochondrial dysfunction and increased susceptibility of the cells to homocysteine, suggests a new mechanism linking CBS deficiency to vascular aging and disease.
deficiency to vascular aging and disease.  +
Has info [ PMID: 23117410 Open Access]  +
Has publicationkeywords Methionine  + , Cysteine  + , Cystathionine beta synthase  +
Has title Albertini E, Kozieł R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Aging (Albany NY) 4:664-73.  +
Instrument and method Oxygraph-2k  +
Mammal and model Human  +
MiP area Respiration  + , Genetic knockout;overexpression  +
Preparation Intact cells  +
Respiration and regulation mt-Membrane potential  +
Tissue and cell Endothelial;epithelial;mesothelial cell  + , HUVEC  +
Was published by MiPNetLab AT Innsbruck Jansen-Duerr P +
Was published in journal Aging (Albany NY) +
Was published in year 2012  +
Was written by Albertini E + , Koziel R + , Duerr A + , Neuhaus M + , Jansen-Duerr P +
Categories Publications
Modification date
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12:06:41, 26 March 2018  +
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