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Astrakhanova 2018 Sovrem Tekhnologii Med
Additional label 2019-02  +
Coupling states OXPHOS  + , LEAK  +
Has abstract The aim of the study was to study the effe
The aim of the study was to study the effect of TrkB-mediated action of the brain-derived neurotrophic factor (BDNF) on animal survival and mitochondrial respiratory chain activity in acute hypobaric hypoxia model ''in vivo''. ''In vivo'' experiments were performed on mature male CBA mice weighing 20–25 g. In order to modulate acute hypobaric hypoxia, the animals were placed in the hypobaric chamber (220–240 mm Hg) which simulates conditions corresponding to the altitude of 10 000 m above sea level. The oxygen consumption rate by the brain mitochondria under the hypoxic influence was evaluated using a high-resolution OROBOROS Oxygraph-2k respirometer (OROBOROS Instruments, Austria). Preventive BDNF application has been established to increase the survival of the CBA-line animals after acute hypobaric hypoxia modeling and to influence favorably the work of mitochondrial respiratory chain complex I. BDNF increases animal resistance to acute hypobaric hypoxia and influences the work of mitochondrial respiratory chain through TrkB-signaling mechanisms. Antihypoxic effect of BDNF is realized by maintaining the activity of NADH-dependent pathway of substrate oxidation and ATP synthesis.
of substrate oxidation and ATP synthesis.  +
Has editor [[Plangger M]]  +
Has info [ Open Access]  +
Has publicationkeywords Brain-derived neurotrophic factor  + , BDNF  + , TrkB-signaling  + , Acute hypobaric hypoxia  + , Oxidative phosphorylation  + , Neuroprotection  +
Has title Astrakhanova ТА, Urazov МD, Usenko АV, Mitroshina ЕV, Mishchenko ТА, Schelchkova NА, Vedunova МV (2018) BDNF-mediated regulation of the brain mitochondria functional state in hypoxia. Sovrem Tekhnologii Med 10:88-94.  +
Instrument and method Oxygraph-2k  +
Mammal and model Mouse  +
MiP area Respiration  + , Pharmacology;toxicology  +
Pathways N  + , S  +
Preparation Isolated mitochondria  +
Stress Hypoxia  +
Tissue and cell Nervous system  +
Was published in journal Sovrem Tekhnologii Med +
Was published in year 2018  +
Was written by Astrakhanova ТА + , Urazov МD + , Usenko АV + , Mitroshina ЕV + , Mishchenko ТА + , Schelchkova NА + , Vedunova МV +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
08:12:40, 24 June 2019  +
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