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Porter 2017 Adipocyte
Additional label 2019-03  +
Coupling states LEAK  + , ROUTINE  + , OXPHOS  + , ET  +
Enzyme Uncoupling protein  +
Has abstract Brown adipose tissue (BAT) mitochondria ar
Brown adipose tissue (BAT) mitochondria are distinct from their counterparts in other tissues in that ATP production is not their primary physiologic role. BAT mitochondria are equipped with a specialized protein known as uncoupling protein 1 (UCP1). UCP1 short-circuits the electron transport chain, allowing mitochondrial membrane potential to be transduced to heat, making BAT a tissue capable of altering energy expenditure and fuel metabolism in mammals without increasing physical activity. The recent discovery that adult humans have metabolically active BAT has rekindled an interest in this intriguing tissue, with the overarching aim of manipulating BAT function to augment energy expenditure as a countermeasure for obesity and the metabolic abnormalities it incurs. Subsequently, there has been heightened interest in quantifying BAT function and more specifically, determining UCP1-mediated thermogenesis in BAT specimens - including in those obtained from humans. In this article, BAT mitochondrial bioenergetics will be described and compared with more conventional mitochondria in other tissues. The biochemical methods typically used to quantify BAT mitochondrial function will also be discussed in terms of their specificity for assaying UCP1 mediated thermogenesis. Finally, recent data concerning BAT UCP1 function in humans will be described and discussed.
in humans will be described and discussed.  +
Has editor [[Plangger M]]  +
Has info [https://www.ncbi.nlm.nih.gov/pubmed/28453364 PMID: 28453364 Open Access]  +
Has publicationkeywords Brown fat  + , GDP  + , UCP1  + , Mitochondria  + , Thermogenesis  + , Review  +
Has title Porter C (2017) Quantification of UCP1 function in human brown adipose tissue. Adipocyte 6:167-74.  +
Instrument and method Oxygraph-2k  +
MiP area Respiration  +
Preparation Permeabilized tissue  + , Isolated mitochondria  + , Intact cells  +
Tissue and cell Fat  +
Was published by MiPNetLab US TX Galveston Porter C +
Was published in journal Adipocyte +
Was published in year 2017  +
Was written by Porter C +
Categories Publications
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
08:37:28, 16 August 2019  +
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