Search results

• Rigoni 2016 Abstract Mito Xmas Meeting Innsbruck
  |title=Nucleoids and mtDNA dynamics regulation by mitochondrial ultrastructure. ...for nucleoids and mtDNA stability. Our results suggest that nucleoids and mtDNA stability is regulated by mitochondrial ultrastructure.
  1 KB (200 words) - 17:23, 14 December 2016
• Johnston 2015 Abstract MiPschool London 2015
  ...ng, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism. ...certainty surrounding this process limits our ability to address inherited mtDNA diseases.
  2 KB (231 words) - 15:39, 10 April 2015
• Shadel 2005 Trends Biochem Sci
  ...called nucleoids. In this novel context, aconitase functions to stabilize mtDNA, perhaps by reversibly remodeling nucleoids to directly influence mitochond
  997 bytes (131 words) - 02:54, 5 November 2023
• Yardeni 2023 MiP2023
  ...iety of human diseases including obesity. However, the mechanisms by which mtDNA variation and the gut microbiota modulate disease risk remains unknown. Our ...differences in gut microbiota in our conplastic mice which differ in their mtDNA lineages. Further, the transfer of the gut microbiota from a host of one mi
  2 KB (314 words) - 15:29, 18 July 2023
• Lee 2015 Methods Mol Biol
  ...induced pluripotent stem cells; determine DNA methylation patterns of the mtDNA-specific replication factors; and assess mitochondrial OXPHOS capacity. |keywords=Differentiation, Mitochondrial DNA, OXPHOS, POLGA, Pluripotency, mtDNA replication
  2 KB (302 words) - 15:07, 13 November 2017
• Eide 2014 Abstract MiP2014
  ...equency with mtRNA integrity allows us to estimate the tolerance level for mtDNA mutation frequency. ...A, thereby providing an explanation for the apparent high tolerance for ES mtDNA mutations.
  2 KB (291 words) - 16:21, 9 November 2016
• Martinez 2015 Thesis
  ...lares para el estudio del efecto fenotipico de la variacion genetica en el mtDNA. Thesis 1-35. ...molecules placed in mitochondria and known as mitochondrial DNA (mtDNA). mtDNA encodes 13 subunits very important for the oxidative phosphorylation syste
  1 KB (193 words) - 14:20, 9 November 2016
• Zapico 2013 Aging Dis
  |title=Zapico SC, Ubelaker DH (2013) mtDNA mutations and their role in aging, diseases and forensic sciences. Aging Di ...ience research. Therefore this review will help to clarify the key role of mtDNA mutations in these processes and support further research in this area.
  2 KB (263 words) - 21:45, 18 December 2023
• Ghanim 2014 Abstract EUROMIT
  ...every year. Numerous studies of mtDNA in cancer have shown differences in mtDNA sequences between tumor and normal tissue and at various stages of cancer t ...ne sequence were examined, whereas in the remaining six patients the whole mtDNA sequence was studied. In some patients polymorphisms whose levels varied du
  1 KB (198 words) - 14:02, 19 April 2017
• Triska 2019 Cancer Res
  ...ape of germline and tumor mtDNA mutations and identifies hotspots of tumor mtDNA mutations to pinpoint key mitochondrial functions in pediatric malignancies |area=mtDNA;mt-genetics
  2 KB (262 words) - 19:20, 29 January 2024
• Holt 1988 Nature
  ...etions of up to 7 kilobases in length. These observations demonstrate that mtDNA heteroplasmy can occur in man and that human disease may be associated with
  2 KB (212 words) - 16:19, 13 September 2023
• Correa 2012 Mitochondrion
  ...hole individuals. The results show that a small set of naturally occurring mtDNA mutations can have a significant influence on mitochondrial bioenergetics t |keywords=Mitochondrial bioenergetics, Reactive oxygen species, mtDNA copy number
  1 KB (189 words) - 17:26, 9 November 2017
• Pezet 2021 Commun Biol
  ...drial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro. https://doi.org/10.1038/s42003-021-02069-2 ...during early development likely modulate the amount of mtDNA, facilitating mtDNA segregation and contributing to tissue-specific mutation loads.
  2 KB (239 words) - 23:12, 15 July 2022
• Dickinson 2013 Thesis University of Warwick - Great Britain
  cells. Mitochondria contain their own genome, mitochondrial DNA (mtDNA) that generator of cellular energy. Precise regulation of mtDNA copy number is
  3 KB (384 words) - 17:45, 9 November 2017
• Eynon 2011 Physiol Genomics
  ...obic performance, characterized by maximal oxygen uptake (VO2max). Whether mtDNA haplogroups are also associated with the status of being an elite endurance |area=mtDNA;mt-genetics, Exercise physiology;nutrition;life style
  2 KB (209 words) - 15:02, 17 February 2015
• Dickinson 2013 Cell Death Differ
  ...the tumor formation process. These outcomes demonstrate the importance of mtDNA to the initiation and maintenance of tumorigenesis in glioblastoma multifor ...(mtDNA), Glioblastoma multiforme (GBM), Tumorigenesis, mtDNA copy number, mtDNA set point, ATP, human neural stem cells, glioblastoma cells
  3 KB (361 words) - 17:45, 9 November 2017
• DeBalsi 2017 Ageing Res Rev
  ...repair these mtDNA errors results in mtDNA mutations. Clonal expansion of mtDNA mutations results in mitochondrial dysfunction, such as decreased electron
  2 KB (213 words) - 12:22, 22 October 2023
• Ruiz-Pesini 2004 Science
  ...Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 303:223-6. ...ensity for energy deficiency diseases as well as longevity. Thus, specific mtDNA replacement mutations permitted our ancestors to adapt to more northern cli
  1 KB (179 words) - 12:23, 26 February 2015
• Caro 2010 Mitochondrion
  ...hepatocytes. Bone marrow metaphase cells from both young and old rats show mtDNA at centromeric regions in 20 out of the 2n=40 chromosomes. Consequently, mi |area=mtDNA;mt-genetics, nDNA;cell genetics
  2 KB (279 words) - 16:06, 12 October 2016
• Bratic 2013 J Clin Invest
  ...t caused by damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur during development. Here we discuss the cavea |area=mt-Biogenesis;mt-density, mtDNA;mt-genetics, Comparative MiP;environmental MiP, mt-Medicine, Pharmacology;t
  2 KB (216 words) - 18:50, 9 October 2023

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