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Wikstroem Marten KF

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Name Wikström Marten K.F., MD, PhD,

Professor Emeritus, Physical Biochemistry

Institution Institute of Biotechnology
Marten Wikstroem

University of Helsinki

In memoriam, MÄrten Wikström (1945-2024)

Address ,
City Helsinki
State/Province
Country Finland
Email
Weblink
O2k-Network Lab FI Helsinki Wikstroem M


Labels: Field of research: Basic 



Publications

 PublishedReference
Wikstroem 2023 Enzymes2023Wikström M, Pecorilla C, Sharma V (2023) The mitochondrial respiratory chain. Enzymes 54:15-36. https://doi.org/10.1016/bs.enz.2023.05.001
Wikstroem 2023 Biochim Biophys Acta Bioenerg2023Wikström M, Gennis RB, Rich PR (2023) Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase. Biochim Biophys Acta Bioenerg 1864:148933. https://doi.org/10.1016/j.bbabio.2022.148933
Wikstroem 2023 FEBS Lett2023Wikström M, Djurabekova A, Sharma V (2023) On the role of ubiquinone in the proton translocation mechanism of respiratory complex I. FEBS Lett 597:224-36. https://doi.org/10.1002/1873-3468.14506
Saura 2022 Proc Natl Acad Sci U S A2022Saura P, Riepl D, Frey DM, Wikström M, Kaila VRI (2022) Electric fields control water-gated proton transfer in cytochrome c oxidase. Proc Natl Acad Sci U S A 119:e2207761119. https://doi.org/10.1073/pnas.2207761119
Kaila 2021 Nat Rev Microbiol2021Kaila VRI, Wikström M (2021) Architecture of bacterial respiratory chains. Nat Rev Microbiol 19:319-30. https://doi.org/10.1038/s41579-020-00486-4
Siletsky 2021 Biochim Biophys Acta Bioenerg2021Siletsky SA, Soulimane T, Belevich I, Gennis RB, Wikström M (2021) Specific inhibition of proton pumping by the T315V mutation in the K channel of cytochrome ba3 from Thermus thermophilus. Biochim Biophys Acta Bioenerg 1862:148450. https://doi.org/10.1016/j.bbabio.2021.148450
Wikstroem 2020 Commun Biol2020Wikström M, Springett R (2020) Thermodynamic efficiency, reversibility, and degree of coupling in energy conservation by the mitochondrial respiratory chain. Commun Biol 3:451. https://doi.org/10.1038/s42003-020-01192-w
Purhonen 2020 Nat Commun2020Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, KallijÀrvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.
Wikstroem 2018 Chem Rev2018Wikström M, Krab K, Sharma V (2018) Oxygen activation and energy conservation by cytochrome c oxidase. Chem Rev 118:2469-90. https://doi.org/10.1021/acs.chemrev.7b00664
Wikstroem 2018 Biochim Biophys Acta Bioenerg2018Wikström M, Sharma V (2018) Proton pumping by cytochrome c oxidase - a 40 year anniversary. Biochim Biophys Acta Bioenerg 1859:692-8. https://doi.org/10.1016/j.bbabio.2018.03.009
Warnau 2018 Proc Natl Acad Sci U S A2018Warnau J, Sharma V, Gamiz-Hernandez AP, Di Luca A, Haapanen O, Vattulainen I, Wikström M, Hummer G, Kaila VRI (2018) Redox-coupled quinone dynamics in the respiratory complex I. Proc Natl Acad Sci U S A 115:E8413-20. https://doi.org/10.1073/pnas.1805468115
Siletsky 2017 Biochim Biophys Acta Bioenerg2017Siletsky SA, Belevich I, Belevich NP, Soulimane T, Wikström M (2017) Time-resolved generation of membrane potential by ba3 cytochrome c oxidase from Thermus thermophilus coupled to single electron injection into the O and OH states. Biochim Biophys Acta Bioenerg 1858:915-26. https://doi.org/10.1016/j.bbabio.2017.08.007
Liang 2017 Proc Natl Acad Sci U S A2017Liang R, Swanson JMJ, Wikström M, Voth GA (2017) Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase. Proc Natl Acad Sci U S A 114:5924-9. https://doi.org/10.1073/pnas.1703654114
Sharma 2016 Biochim Biophys Acta2016Sharma V, Wikström M (2016) The role of the K-channel and the active-site tyrosine in the catalytic mechanism of cytochrome c oxidase. Biochim Biophys Acta 1857:1111-5. https://doi.org/10.1016/j.bbabio.2016.02.008
Hummer 2016 Biochim Biophys Acta2016Hummer G, Wikström M (2016) Molecular simulation and modeling of complex I. Biochim Biophys Acta 1857:915-21. https://doi.org/10.1016/j.bbabio.2016.01.005
Liang 2016 Proc Natl Acad Sci U S A2016Liang R, Swanson JM, Peng Y, Wikström M, Voth GA (2016) Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome c oxidase. Proc Natl Acad Sci U S A 113:7420-5. https://doi.org/10.1073/pnas.1601982113
Sharma 2015 Proc Natl Acad Sci U S A2015Sharma V, Enkavi G, Vattulainen I, Róg T, Wikström M (2015) Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase. Proc Natl Acad Sci U S A 112:2040-5. https://doi.org/10.1073/pnas.1409543112
Wikstroem 2015 Chem Rev2015Wikström M, Sharma V, Kaila VR, Hosler JP, Hummer G (2015) New perspectives on proton pumping in cellular respiration. Chem Rev 115:2196-221. https://doi.org/10.1021/cr500448t
Sharma V 2015 Proc Natl Acad Sci U S A2015Sharma V, Belevich G, Gamiz-Hernandez AP, Róg T, Vattulainen I, Verkhovskaya ML, Wikström M, Hummer G, Kaila VR (2015) Redox-induced activation of the proton pump in the respiratory Complex I. Proc Natl Acad Sci U S A 112:11571-6. https://doi.org/10.1073/pnas.1503761112
Kaila 2014 Proc Natl Acad Sci U S A2014Kaila VR, Wikström M, Hummer G (2014) Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory Complex I. Proc Natl Acad Sci U S A 111:6988-93. https://doi.org/10.1073/pnas.1319156111
Sharma 2014 FEBS Lett2014Sharma V, Wikström M (2014) A structural and functional perspective on the evolution of the heme-copper oxidases. FEBS Lett 588:3787-92. https://doi.org/10.1016/j.febslet.2014.09.020
Verkhovskaya 2014 Biochim Biophys Acta2014Verkhovskaya M, Wikström M (2014) Oxidoreduction properties of bound ubiquinone in Complex I from Escherichia coli. Biochim Biophys Acta 1837:246-50. https://doi.org/10.1016/j.bbabio.2013.11.001
Sharma 2013 Proc Natl Acad Sci U S A2013Sharma V, Karlin KD, Wikström M (2013) Computational study of the activated O(H) state in the catalytic mechanism of cytochrome c oxidase. Proc Natl Acad Sci U S A 110:16844-9. https://doi.org/10.1073/pnas.1220379110
Wikstroem 2012 Proc Natl Acad Sci U S A2012Wikström M, Hummer G (2012) Stoichiometry of proton translocation by respiratory complex I and its mechanistic implications. Proc Natl Acad Sci U S A 109:4431-6.
Babcock 1992 Nature1992Babcock GT, Wikström M (1992) Oxygen activation and the conservation of energy in cell respiration. Nature 356:301-9.
Wikstroem 1979 Biochim Biophys Acta1979Wikstroem MKF, Krab K (1979) Proton-pumping cytochrome c oxidase. Biochim Biophys Acta 549:177-222.
Wikstroem 1977 Nature1977Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266:271-3.
Akerman 1976 FEBS Lett1976Akerman KEO, Wikström MKF (1976) Safranine as a probe of the mitochondrial membrane potential. FEBS Lett 68:191-7.

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