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 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Dent 2019 J Appl Physiol (1985)2019Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Derungs 2017 Mol Psychiatry2017Derungs R, Camici GG, Spescha RD, Welt T, Tackenberg C, Späni C, Wirth F, Grimm A, Eckert A, Nitsch RM, Kulic L (2017) Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease. Mol Psychiatry 22:605-14.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseNervous system
Deschaseaux 2018 US Patent2018Deschaseaux F, Guilloton F, Muller S, Sensebe L, Casteilla L, Carriere-Pazat A (2018) Method for obtaining human brown/beige adipocytes . US Patent US20180216070A1.LEAK
ROUTINE
ET
ROXIntact cellsHumanFat
Deschauer 2006 Mol Genet Metab2006Deschauer M, Gizatullina Z, Schulze A, Pritsch M, Knöppel C, Knape M, Zierz S, Gellerich FN (2006) Molecular and biochemical investigations in fumarase deficiency. Mol Genet Metab 88:146-52.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Deschemin 2023 Sci Rep2023Deschemin JC, Ransy C, Bouillaud F, Chung S, Galy B, Peyssonnaux C, Vaulont S (2023) Hepcidin deficiency in mice impairs white adipose tissue browning possibly due to a defect in de novo adipogenesis. https://doi.org/10.1038/s41598-023-39305-0LEAK
OXPHOS
ET
SHomogenateMouseFat
Desjardins 2022 Proc Natl Acad Sci U S A2022Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR (2022) The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids. https://doi.org/10.1073/pnas.2119824119LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseLiver
Desmoulins 2019 Mol Metab2019Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77.OXPHOS
ET
LEAK
N
NS
HomogenateRatNervous system
Desprat 2015 Thesis2015Desprat JL, Teulier L, Puijalon S, Romestaing C, Dumet A, Lengagne T, Mondy N (2015) Caloric restriction and testosterone affect mitochondrial functioning and contractile properties of calling muscles in Hyla arborea.. Doctoral Thesis p153.LEAK
OXPHOS
F
NS
Permeabilized tissueAmphibiansSkeletal muscle
Desprat 2017 Comp Biochem Physiol A Mol Integr Physiol2017Desprat JL, Teulier L, Puijalon S, Dumet A, Romestaing C, Tattersall GJ, Lengagne T, Mondy N (2017) Doping for sex: Bad for mitochondrial performances? Case of testosterone supplemented Hyla arborea during the courtship period. Comp Biochem Physiol A Mol Integr Physiol 209:74-83.OXPHOS
ET
LEAK
F
NS
Permeabilized tissueAmphibiansSkeletal muscle
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis2019Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Detaille 2019 PLoS One2019Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatHeart
Deutschman 2019 J Cell Sci2019Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Devaux 2015 Abstract MiP2015Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.LEAK
OXPHOS
ET
N
S
HomogenateFishesNervous system
Devaux 2019 Front Physiol2019Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941.LEAK
OXPHOS
ET
Other combinations
N
NS
Permeabilized tissue
Isolated mitochondria
FishesNervous system
Devaux 2019 J Exp Biol2019Devaux JBL, Hickey AJR, Renshaw GMC (2019) Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/reoxygenation. J Exp Biol 222:jeb191353.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
HomogenateFishesNervous system
Devaux 2023 J Comp Physiol B2023Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). https://doi.org/10.1007/s00360-023-01495-4LEAK
OXPHOS
ET
N
S
NS
CIV
Permeabilized cellsFishesNervous system
Devin 1997 Biochim Biophys Acta1997Devin A, Guerin B, Rigoulet M (1997) Control of oxidative phosphorylation in rat liver mitochondria: effect of ionic media. Biochim Biophys Acta 1319:293-300.LEAK
OXPHOS
ET
NIsolated mitochondriaRatLiver
Dewidar 2023 EBioMedicine2023Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. https://doi.org/10.1016/j.ebiom.2023.104714LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Liver
Diana 2015 Br J Surg2015Diana M, Agnus V, Halvax P, Liu YY, Dallemagne B, Schlagowski AI, Geny B, Diemunsch P, Lindner V, Marescaux J (2015) Intraoperative fluorescence-based enhanced reality laparoscopic real-time imaging to assess bowel perfusion at the anastomotic site in an experimental model. Br J Surg 102:e169-76.LEAK
OXPHOS
Permeabilized tissuePigEndothelial;epithelial;mesothelial cell
Diana 2015 Obes Surg2015Diana M, Pop R, Beaujeux R, Dallemagne B, Halvax P, Schlagowski I, Liu YY, Diemunsch P, Geny B, Lindner V, Marescaux J (2015) Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. proof of the concept in the porcine model.. Obes Surg 25:550-8.LEAK
OXPHOS
Permeabilized tissuePigEndothelial;epithelial;mesothelial cell
Diana 2015 Surg Innov2015Diana M, Noll E, Diemunsch P, Moussallieh FM, Namer IJ, Charles AL, Lindner V, Agnus V, Geny B, Marescaux J (2015) Metabolism-guided bowel resection: potential role and accuracy of instant capillary lactates to identify the optimal resection site. Surg Innov 22:453-61.LEAK
OXPHOS
N
S
CIV
PigEndothelial;epithelial;mesothelial cell
Diana 2016 Surg Endosc2016Diana M, Noll E, Charles AL, Diemunsch P, Geny B, Liu YY, Marchegiani F, Schiraldi L, Agnus V, Lindner V, Swanström L, Dallemagne B, Marescaux J (2016) Precision real-time evaluation of bowel perfusion: accuracy of confocal endomicroscopy assessment of stoma in a controlled hemorrhagic shock model. Surg Endosc 31:680-91.OXPHOS
LEAK
SPermeabilized tissuePigEndothelial;epithelial;mesothelial cell
Diao 2019 Brain Res2019Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res 1727:146514.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseNervous system
Dias 2016 Neurobiol Aging2016Dias C, Lourenço CF, Ferreiro E, Barbosa RM, Laranjinha J, Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiol Aging 46:84-95.LEAK
ET
N
S
ROX
Permeabilized tissueMouseNervous system
Dias 2018 Anal Biochem2018Dias C, Lourenco CF, Barbosa RM, Laranjinha J, Ledo A (2018) Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices. Anal Biochem 551:43-50.LEAK
ROUTINE
ET
ROXIntact cellsMouse
Rat
Nervous system
Diaz 2023 Front Mol Biosci2023Diaz EC, Adams SH, Weber JL, Cotter M, Børsheim E (2023) Elevated LDL-C, high blood pressure, and low peak V˙O2 associate with platelet mitochondria function in children-The Arkansas Active Kids Study. Front Mol Biosci 10:1136975. https://doi.org/10.3389/fmolb.2023.1136975LEAK
ROUTINE
ET
N
S
Permeabilized cellsHumanBlood cells
Platelet
Dickinson 1967 Science1967Dickinson DB, Misch MJ, Drury RE (1967) Dimethyl sulfoxide protects tightly coupled mitochondria from freezing damage. Science 156:1738-9.LEAK
OXPHOS
Isolated mitochondriaPlants
Dickinson 2013 Cell Death Differ2013Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RDW, McKenzie M, Johns TG, St. John JC (2013) The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ 20:1644–53.LEAK
ROUTINE
ET
ROXHumanNervous system
Other cell lines
Dickinson 2013 Thesis University of Warwick - Great Britain2013Dickinson A (2013) The role of mitochondrial DNA in tumorigenesis. Thesis University of Warwick - Great Britain 292pp.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Diebold 2019 Nat Metab2019Diebold LP, Gil HJ, Gao P, Martinez CA, Weinberg SE, Chandel NS (2019) Mitochondrial Complex III is necessary for endothelial cell proliferation during angiogenesis. Nat Metab 1:158–71.LEAK
ROUTINE
ROXIntact cellsHumanHUVEC
Dieter 2022 Int J Mol Sci2022Dieter F, Esselun C, Eckert GP (2022) Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. https://doi.org/10.3390/ijms23169186LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanNeuroblastoma
Dikov 2010 Exp Gerontol2010Dikov D, Aulbach A, Muster B, Dröse S, Jendrach M, Bereiter-Hahn J (2010) Do UCP2 and mild uncoupling improve longevity? Exp Gerontol 45:586-95.LEAK
ROUTINE
ET
Intact cellsHeLa
Fibroblast
HUVEC
Dilberger 2019 Nutrients2019Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Dilberger 2019 Oxid Med Cell Longev2019Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U, Eckert GP (2019) Mitochondrial oxidative stress impairs energy metabolism and reduces stress resistance and longevity of C. elegans. Oxid Med Cell Longev 2019:6840540.LEAK
ROUTINE
ET
N
S
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Dirks 2020 J Physiol2020Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Distefano 2016 J Gerontol A Biol Sci Med Sci2016Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Distefano 2017 MiPschool Obergurgl
Giovanna Distefano

Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.

LEAK
OXPHOS
ET
F
NS
Permeabilized tissueHumanSkeletal muscle
Distefano 2018 J Cachexia Sarcopenia Muscle2018Distefano G, Standley RA, Zhang X, Carnero EA, Yi F, Cornnell HH, Coen PM (2018) Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle 9:279-94.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Divakaruni 2014 Curr Protoc Toxicol2014Divakaruni AS, Rogers GW, Murphy AN (2014) Measuring mitochondrial function in permeabilized cells using the Seahorse XF Analyzer or a clark-type oxygen electrode. Curr Protoc Toxicol 60:25.2.1-25.2.16.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Permeabilized cellsMouseSkeletal muscle
Other cell lines
Dixit 2017 Free Radic Biol Med2017Dixit S, Fessel JP, Harrison FE (2017) Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Free Radic Biol Med 112:515-23.LEAK
OXPHOS
NIsolated mitochondriaMouseHeart
Djafarzadeh 2011 Mitochondrion2011Djafarzadeh S, Vuda M, Takala J, Ochs M, Jakob SM (2011) Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion 11:83-8.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanLiver
Djafarzadeh 2012 PLoS One2012Djafarzadeh S, Vuda M, Takala J, Jakob SM (2012) Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. PLoS One 7:e45195.LEAK
OXPHOS
ET
N
S
CIV
Isolated mitochondriaHumanLiver
Djafarzadeh 2017b J Vis Exp2017Djafarzadeh S, Jakob SM (2017) Isolation of intact mitochondria from skeletal muscle by differential centrifugation for High-Resolution Respirometry measurements. J Vis Exp doi: 10.3791/55251.LEAK
OXPHOS
N
S
CIV
NS
Isolated mitochondriaSkeletal muscle
Djeungoue-Petga 2019 Cell Death Dis2019Djeungoue-Petga MA, Lurette O, Jean S, Hamel-Côté G, Martín-Jiménez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Dlaskova 2019 Biochim Biophys Acta Bioenerg2019Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg 1860:659-78.LEAK
ET
N
ROX
Intact cellsHumanLiver
Docherty 2016 Stem Cell Res Ther2016Docherty CK, Salt IP, Mercer JR (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Res Ther 7:78.LEAK
ET
ROXIntact cellsHumanKidney
HEK
Doerrier 2012 Abstract BioblastDoerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseHeart
Doerrier 2014 Abstract SECFEvaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseHeart
Doerrier 2014 Life Sci2014Doerrier C, García JA, Volt H, Díaz-Casado ME, Lima-Cabello E, Ortiz F, Luna-Sánchez M, Escames G, López LC, Acuña-Castroviejo D (2014) Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry. Life Sci 121:158-65.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseLiver
Doerrier 2015 Abstract MiP2015Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.LEAK
OXPHOS
SIsolated mitochondriaMouseHeart
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