Hroudova 2013 Mitochondrion
[[Has title::HroudovΓ‘ J, FiΕ‘ar Z, KitzlerovΓ‘ E, ZvΔΕovΓ‘ M, Raboch J (2013) Mitochondrial respiration in blood platelets of depressive patients. Mitochondrion 2013 May 17. pii: S1567-7249(13)00079-2. doi: 10.1016/j.mito.2013.05.005. [Epub ahead of print].]] |
Β» [[Has info::PMID: 23688905]]
Hroudova J, Fisar Z, Kitzlerova E, Zverova M, Raboch J (2013) Mitochondrion
Abstract: Recent evidences include mitochondrial dysfunctions in pathophysiology of mood disorders. We examined association between depressive disorders and mitochondrial respiration using both intact and permeabilized blood platelets. In intact platelets, physiological respiration, maximal capacity of electron transport system and respiratory rate after Complex I inhibition were decreased in depressive patients, who reached partial remission, compared to healthy controls. Respiratory rates were unchanged in several respiratory states in permeabilized platelets. Results indicate that changes in respiratory rate in intact platelets can be used as biological marker of depressive disorder. Hypothesis was supported that decreased mitochondrial respiratory rate participate in pathophysiology of depression.
β’ O2k-Network Lab: CZ Prague Fisar Z
Labels:
Stress:Mitochondrial Disease; Degenerative Disease and Defect Organism: Human Tissue;cell: Blood Cell; Suspension Culture Preparation: Intact Cell; Cultured; Primary, Permeabilized cells
Coupling state: ROUTINE, ETS
HRR: Oxygraph-2k