Difference between revisions of "Cecatto 2020 Mitochondrion"
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|keywords=Cis-5-tetradecenoic acid, Liver mitochondria, Mitochondrial homeostasis, Mitochondrial permeability transition, Myristic acid, VLCAD deficiency | |keywords=Cis-5-tetradecenoic acid, Liver mitochondria, Mitochondrial homeostasis, Mitochondrial permeability transition, Myristic acid, VLCAD deficiency | ||
|editor=[[Plangger M]], | |editor=[[Plangger M]], | ||
|mipnetlab=BR Porto Alegre Souza DOG | |||
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|area=Respiration | |area=Respiration, Pharmacology;toxicology | ||
|diseases=Other | |||
|injuries=Permeability transition | |||
|organism=Rat | |||
|tissues=Liver | |||
|preparations=Permeabilized cells, Isolated mitochondria | |||
|couplingstates=LEAK, OXPHOS, ET | |||
|pathways=N, S | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Labels, 2019-11, | |additional=Labels, 2019-11, | ||
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Revision as of 15:12, 12 November 2019
Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2019) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13. |
Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2019) Mitochondrion
Abstract: Patients affected by very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency commonly present liver dysfunction whose pathogenesis is poorly known. We demonstrate here that major metabolites accumulating in this disorder, namely cis-5-tetradecenoic acid (Cis-5) and myristic acid (Myr), markedly impair mitochondrial respiration, decreasing ATP production in liver mitochondrial preparations from adolescent rats. Other parameters of mitochondrial homeostasis such as membrane potential (ฮฮจm) and Ca2+retention capacity were strongly compromised by these fatty acids, involving induction of mitochondrial permeability transition. The present data indicate that disruption of mitochondrial bioenergetics and Ca2+homeostasis may contribute to the liver dysfunction of VLCAD deficient patients.
Copyright ยฉ 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved. โข Keywords: Cis-5-tetradecenoic acid, Liver mitochondria, Mitochondrial homeostasis, Mitochondrial permeability transition, Myristic acid, VLCAD deficiency โข Bioblast editor: Plangger M โข O2k-Network Lab: BR Porto Alegre Souza DOG
Labels: MiParea: Respiration, Pharmacology;toxicology
Pathology: Other
Stress:Permeability transition
Organism: Rat
Tissue;cell: Liver
Preparation: Permeabilized cells, Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S
HRR: Oxygraph-2k
Labels, 2019-11