Difference between revisions of "GM-pathway control state"
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Revision as of 12:10, 19 November 2016
- high-resolution terminology - matching measurements at high-resolution
GM-pathway control state
Description
MitoPathway control state: N
When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of oxaloacetate, comparable to the metabolism with acetyl-CoA and citrate synthase.
Abbreviation: GM
Reference: Gnaiger 2014 MitoPathways - Chapter 3.4
MitoPedia concepts:
SUIT state
GM(L)
GM(P)
GM(E)
Discussion
- In human skeletal muscle mitochondria, respiration with GM in the presence of ADP (GMP) is identical or 10% higher than with PM (PMP). These results on isolated mitochondria agree with permeabilized fibres, although there are reports on respiratory capacity for PMP being 16% to 25% higher than for GMP. In fibroblasts, GMP supports a higher respiratory flux than PMP.
