Difference between revisions of "LEAK respiration"
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{{MitoPedia | {{MitoPedia | ||
|abbr= | |abbr=''L'' | ||
|description=LEAK oxygen flux, compensating for proton leak, slip and cation cycling, is measured as mitochondrial respiration in state ''L'', in the presence of reducing substrate(s), but absence of inorganic phosphate or ADP, or after inhibition of the [[phosphorylation system]]. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined by the [[proton leak]] and the [[H+/O ratio]]. In this state of maximum protonmotive force, LEAK respiration is higher than the LEAK component in state ''P'' ([[OXPHOS capacity]]). | |description='''LEAK respiration''' or LEAK oxygen flux, compensating for proton leak, slip and cation cycling, is measured as mitochondrial respiration in state ''L'', in the presence of reducing substrate(s), but absence of inorganic phosphate or ADP, or after inhibition of the [[phosphorylation system]]. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined by the [[proton leak]] and the [[H+/O ratio]]. In this state of maximum protonmotive force, LEAK respiration is higher than the LEAK component in state ''P'' ([[OXPHOS capacity]]). | ||
|info=MiPNet12.15, | |info=[[MiPNet12.15]], [[Gnaiger_2009_IJBCB]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
|topics=Respiration; OXPHOS; ETS Capacity, Coupling; Membrane Potential | |||
}} | }} | ||
Revision as of 22:26, 18 September 2010
- high-resolution terminology - matching measurements at high-resolution
LEAK respiration
Description
LEAK respiration or LEAK oxygen flux, compensating for proton leak, slip and cation cycling, is measured as mitochondrial respiration in state L, in the presence of reducing substrate(s), but absence of inorganic phosphate or ADP, or after inhibition of the phosphorylation system. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined by the proton leak and the H+/O ratio. In this state of maximum protonmotive force, LEAK respiration is higher than the LEAK component in state P (OXPHOS capacity).
Abbreviation: L
Reference: MiPNet12.15, Gnaiger_2009_IJBCB
Labels:
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
